Abstract
Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5652-5655 |
| Number of pages | 4 |
| Journal | Journal of Virology |
| Volume | 64 |
| Issue number | 11 |
| State | Published - 1990 |
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ASJC Scopus subject areas
- Immunology
Cite this
Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. / Ackley, Christopher D.; Yamamoto, Janet K.; Levy, Norman; Pedersen, Niels C; Cooper, Max D.
In: Journal of Virology, Vol. 64, No. 11, 1990, p. 5652-5655.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus
AU - Ackley, Christopher D.
AU - Yamamoto, Janet K.
AU - Levy, Norman
AU - Pedersen, Niels C
AU - Cooper, Max D.
PY - 1990
Y1 - 1990
N2 - Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.
AB - Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.
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M3 - Article
VL - 64
SP - 5652
EP - 5655
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 11
ER -