Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus

Christopher D. Ackley, Janet K. Yamamoto, Norman Levy, Niels C Pedersen, Max D. Cooper

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.

Original languageEnglish (US)
Pages (from-to)5652-5655
Number of pages4
JournalJournal of Virology
Volume64
Issue number11
StatePublished - 1990

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Feline Immunodeficiency Virus
Feline immunodeficiency virus
Cats
T-lymphocytes
cats
T-Lymphocytes
pathogens
Hypergammaglobulinemia
B-Cell Antigen Receptors
Viral Tumor Antigens
Felidae
immunoglobulin G
HIV infections
Virus Diseases
cells
blood serum
Immunoglobulin A
immunoglobulins
B-lymphocytes
Immunoglobulin M

ASJC Scopus subject areas

  • Immunology

Cite this

Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. / Ackley, Christopher D.; Yamamoto, Janet K.; Levy, Norman; Pedersen, Niels C; Cooper, Max D.

In: Journal of Virology, Vol. 64, No. 11, 1990, p. 5652-5655.

Research output: Contribution to journalArticle

Ackley, Christopher D. ; Yamamoto, Janet K. ; Levy, Norman ; Pedersen, Niels C ; Cooper, Max D. / Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. In: Journal of Virology. 1990 ; Vol. 64, No. 11. pp. 5652-5655.
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