Abstract
The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 496-505 |
| Number of pages | 10 |
| Journal | Developmental Biology |
| Volume | 100 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
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- Developmental Biology
Cite this
Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses. / Wu, Tsung Chieh; Wan, Yu-Jui Yvonne; Chung, Albert E.; Damjanov, Ivan.
In: Developmental Biology, Vol. 100, No. 2, 1983, p. 496-505.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses
AU - Wu, Tsung Chieh
AU - Wan, Yu-Jui Yvonne
AU - Chung, Albert E.
AU - Damjanov, Ivan
PY - 1983
Y1 - 1983
N2 - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.
AB - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.
UR - http://www.scopus.com/inward/record.url?scp=0021049422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021049422&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(83)90242-7
DO - 10.1016/0012-1606(83)90242-7
M3 - Article
VL - 100
SP - 496
EP - 505
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -