Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

Tsung Chieh Wu, Yu-Jui Yvonne Wan, Albert E. Chung, Ivan Damjanov

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

Original languageEnglish (US)
Pages (from-to)496-505
Number of pages10
JournalDevelopmental Biology
Issue number2
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology


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