Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

Tsung Chieh Wu; Yu-Jui Yvonne Wan; Albert E. Chung; Ivan Damjanov

doi:10.1016/0012-1606(83)90242-7

Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

Tsung Chieh Wu, Yu-Jui Yvonne Wan, Albert E. Chung, Ivan Damjanov

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Abstract

The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

Original language	English (US)
Pages (from-to)	496-505
Number of pages	10
Journal	Developmental Biology
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/0012-1606(83)90242-7
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Developmental Biology

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title = "Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses",

abstract = "The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.",

author = "Wu, {Tsung Chieh} and Wan, {Yu-Jui Yvonne} and Chung, {Albert E.} and Ivan Damjanov",

year = "1983",

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T1 - Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

AU - Wu, Tsung Chieh

AU - Wan, Yu-Jui Yvonne

AU - Chung, Albert E.

AU - Damjanov, Ivan

PY - 1983

Y1 - 1983

N2 - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

AB - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

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Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

Abstract

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