Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

Tsung Chieh Wu, Yu-Jui Yvonne Wan, Albert E. Chung, Ivan Damjanov

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

Original languageEnglish (US)
Pages (from-to)496-505
Number of pages10
JournalDevelopmental Biology
Volume100
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Laminin
Fetus
Embryonic Structures
Blastocyst
Membrane Glycoproteins
Basement Membrane
Embryonic Development
Immunohistochemistry
Electrons
Light
nidogen
Antibodies

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses. / Wu, Tsung Chieh; Wan, Yu-Jui Yvonne; Chung, Albert E.; Damjanov, Ivan.

In: Developmental Biology, Vol. 100, No. 2, 1983, p. 496-505.

Research output: Contribution to journalArticle

Wu, Tsung Chieh ; Wan, Yu-Jui Yvonne ; Chung, Albert E. ; Damjanov, Ivan. / Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses. In: Developmental Biology. 1983 ; Vol. 100, No. 2. pp. 496-505.
@article{70df08a5ed85494f84172e4ce7ca63b5,
title = "Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses",
abstract = "The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.",
author = "Wu, {Tsung Chieh} and Wan, {Yu-Jui Yvonne} and Chung, {Albert E.} and Ivan Damjanov",
year = "1983",
doi = "10.1016/0012-1606(83)90242-7",
language = "English (US)",
volume = "100",
pages = "496--505",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

AU - Wu, Tsung Chieh

AU - Wan, Yu-Jui Yvonne

AU - Chung, Albert E.

AU - Damjanov, Ivan

PY - 1983

Y1 - 1983

N2 - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

AB - The temporal appearance and the anatomic distribution of entactin in the developing mouse embryo was studied by light and electron microscopic immunohistochemistry and compared with the appearance and the distribution of laminin. Immunohistochemically detectable entactin first appeared in the hatched blastocysts, in contrast to laminin which became apparent as early as the 8-cell stage of development. However, beginning with the appearance of entactin in the hatched blastocyst, antibodies to these two basement membrane glycoproteins co-localized in all extraembryonic matrices. These findings indicate that the synthesis of entactin and laminin is asynchronous in the early stages of mouse embryonic development but becomes synchronized in the postimplantational stages of development.

UR - http://www.scopus.com/inward/record.url?scp=0021049422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021049422&partnerID=8YFLogxK

U2 - 10.1016/0012-1606(83)90242-7

DO - 10.1016/0012-1606(83)90242-7

M3 - Article

VL - 100

SP - 496

EP - 505

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -