Immunohistochemical expression of renin is a prognostic factor for recurrence in nonmetastatic renal cell carcinoma

Felipe de Almeida e Paula, Stephania Martins Bezerra, Isabela Werneck da Cunha, Guilherme Consentino Munhoz, Diego Abreu, Primo N Lara, Walter Henriques da Costa, Stênio de Cássio Zéqui

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Purpose: To analyze the intratumoral immunohistochemical expression of renin and its value as a prognostic factor for recurrence in nonmetastatic clear cell renal cell carcinoma (ccRCC). Methods: A total of 498 patients with nonmetastatic ccRCC from the Latin American Renal Cancer Group database who underwent partial or radical nephrectomy between 1990 and 2016 were selected. All cases were revised, and 2 distinct samples were obtained for tissue microarray construction. Ten years of follow-up was assessed, and disease-free survival rates (DFS) were analyzed. Renin expression was classified qualitatively as negative or positive. For the quantitative analysis, a cutoff was estimated using the maximum of the standardized log-rank statistic. Results: Nuclear renin was qualitatively positive in 360 cases (72%) and negative in 138 (28%), whereas quantitatively, an equal number of cases had ≤35% or >35% renin-positive nuclei. The absence of renin expression was associated with high-grade tumors (by ISUP and Fuhrman classification, both P < 0.001), greater microscopic venous invasion (P = 0.046), and renal vein invasion (P = 0.026). In the multivariate analyses, qualitatively negative renin expression was an unfavorable prognostic factor for DFS (RR = 2.923, P < 0.001). With regard to quantitative renin expression, a cutoff of ≤35 was associated with worse DFS (RR = 4.085, P < 0.001). Conclusions: The intratumoral immunohistochemical expression of renin in patients with ccRCC provides valuable prognostic data regarding the likelihood of recurrence.

Original languageEnglish (US)
JournalUrologic Oncology: Seminars and Original Investigations
StateAccepted/In press - Jan 1 2019


  • Biomarkers
  • Disease-free survival
  • Kidney Neoplasms
  • Renin

ASJC Scopus subject areas

  • Oncology
  • Urology


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