By using immune sera which recognize one or more of the 3 peptides, somatostatin 14 (SS14), somatostatin-28 (SS28) and somatostatin-281-12) (SS281-12) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS281-12 is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.
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