Immunohistochemical Characterization of Feline Mast Cell Tumors

C. L. Mallett; N. C. Northrup; C. F. Saba; C. O. Rodriguez; K. M. Rassnick; T. L. Gieger; M. O. Childress; E. W. Howerth

doi:10.1177/0300985812441032

Immunohistochemical Characterization of Feline Mast Cell Tumors

C. L. Mallett, N. C. Northrup, C. F. Saba, C. O. Rodriguez, K. M. Rassnick, T. L. Gieger, M. O. Childress, E. W. Howerth

Surgical and Radiological Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

Original language	English (US)
Pages (from-to)	106-109
Number of pages	4
Journal	Veterinary Pathology
Volume	50
Issue number	1
DOIs	https://doi.org/10.1177/0300985812441032
State	Published - Jan 2013

Keywords

cat
CD117
histamine
immunohistochemistry
KIT
oncology
serotonin

ASJC Scopus subject areas

veterinary(all)
Medicine(all)

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title = "Immunohistochemical Characterization of Feline Mast Cell Tumors",

abstract = "Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.",

keywords = "cat, CD117, histamine, immunohistochemistry, KIT, oncology, serotonin",

author = "Mallett, {C. L.} and Northrup, {N. C.} and Saba, {C. F.} and Rodriguez, {C. O.} and Rassnick, {K. M.} and Gieger, {T. L.} and Childress, {M. O.} and Howerth, {E. W.}",

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AU - Mallett, C. L.

AU - Northrup, N. C.

AU - Saba, C. F.

AU - Rodriguez, C. O.

AU - Rassnick, K. M.

AU - Gieger, T. L.

AU - Childress, M. O.

AU - Howerth, E. W.

PY - 2013/1

Y1 - 2013/1

N2 - Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

AB - Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

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KW - CD117

KW - histamine

KW - immunohistochemistry

KW - KIT

KW - oncology

KW - serotonin

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Immunohistochemical Characterization of Feline Mast Cell Tumors

Abstract

Keywords

ASJC Scopus subject areas

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