Immunohistochemical Characterization of Feline Mast Cell Tumors

C. L. Mallett, N. C. Northrup, C. F. Saba, C. O. Rodriguez, K. M. Rassnick, T. L. Gieger, M. O. Childress, E. W. Howerth

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13 Scopus citations


Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalVeterinary Pathology
Issue number1
StatePublished - Jan 2013


  • cat
  • CD117
  • histamine
  • immunohistochemistry
  • KIT
  • oncology
  • serotonin

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)


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