Abstract
Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 106-109 |
| Number of pages | 4 |
| Journal | Veterinary Pathology |
| Volume | 50 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2013 |
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Keywords
- cat
- CD117
- histamine
- immunohistochemistry
- KIT
- oncology
- serotonin
ASJC Scopus subject areas
- veterinary(all)
- Medicine(all)
Cite this
Immunohistochemical Characterization of Feline Mast Cell Tumors. / Mallett, C. L.; Northrup, N. C.; Saba, C. F.; Rodriguez, C. O.; Rassnick, K. M.; Gieger, T. L.; Childress, M. O.; Howerth, E. W.
In: Veterinary Pathology, Vol. 50, No. 1, 01.2013, p. 106-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical Characterization of Feline Mast Cell Tumors
AU - Mallett, C. L.
AU - Northrup, N. C.
AU - Saba, C. F.
AU - Rodriguez, C. O.
AU - Rassnick, K. M.
AU - Gieger, T. L.
AU - Childress, M. O.
AU - Howerth, E. W.
PY - 2013/1
Y1 - 2013/1
N2 - Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
AB - Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
KW - cat
KW - CD117
KW - histamine
KW - immunohistochemistry
KW - KIT
KW - oncology
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=84872838650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872838650&partnerID=8YFLogxK
U2 - 10.1177/0300985812441032
DO - 10.1177/0300985812441032
M3 - Article
C2 - 22492208
AN - SCOPUS:84872838650
VL - 50
SP - 106
EP - 109
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 1
ER -