Immunohistochemical Characterization of Feline Mast Cell Tumors

C. L. Mallett, N. C. Northrup, C. F. Saba, C. O. Rodriguez, K. M. Rassnick, T. L. Gieger, M. O. Childress, E. W. Howerth

Research output: Contribution to journalArticle

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Abstract

Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalVeterinary Pathology
Volume50
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Felidae
mast cells
Mast Cells
cats
neoplasms
Neoplasms
Skin
histamine
serotonin
Histamine
Serotonin
Biogenic Amines
biogenic amines
skin (animal)
gastrointestinal system
immunohistochemistry
Gastrointestinal Tract
spleen
Spleen
Immunohistochemistry

Keywords

  • cat
  • CD117
  • histamine
  • immunohistochemistry
  • KIT
  • oncology
  • serotonin

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Mallett, C. L., Northrup, N. C., Saba, C. F., Rodriguez, C. O., Rassnick, K. M., Gieger, T. L., ... Howerth, E. W. (2013). Immunohistochemical Characterization of Feline Mast Cell Tumors. Veterinary Pathology, 50(1), 106-109. https://doi.org/10.1177/0300985812441032

Immunohistochemical Characterization of Feline Mast Cell Tumors. / Mallett, C. L.; Northrup, N. C.; Saba, C. F.; Rodriguez, C. O.; Rassnick, K. M.; Gieger, T. L.; Childress, M. O.; Howerth, E. W.

In: Veterinary Pathology, Vol. 50, No. 1, 01.2013, p. 106-109.

Research output: Contribution to journalArticle

Mallett, CL, Northrup, NC, Saba, CF, Rodriguez, CO, Rassnick, KM, Gieger, TL, Childress, MO & Howerth, EW 2013, 'Immunohistochemical Characterization of Feline Mast Cell Tumors', Veterinary Pathology, vol. 50, no. 1, pp. 106-109. https://doi.org/10.1177/0300985812441032
Mallett CL, Northrup NC, Saba CF, Rodriguez CO, Rassnick KM, Gieger TL et al. Immunohistochemical Characterization of Feline Mast Cell Tumors. Veterinary Pathology. 2013 Jan;50(1):106-109. https://doi.org/10.1177/0300985812441032
Mallett, C. L. ; Northrup, N. C. ; Saba, C. F. ; Rodriguez, C. O. ; Rassnick, K. M. ; Gieger, T. L. ; Childress, M. O. ; Howerth, E. W. / Immunohistochemical Characterization of Feline Mast Cell Tumors. In: Veterinary Pathology. 2013 ; Vol. 50, No. 1. pp. 106-109.
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