Immunoglobulin-like receptors and their impact on wiring of brain synapses

Scott Cameron, A Kimberley Usrey

Research output: Contribution to journalReview article

Abstract

Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, focusing on examples from three classes of IgSF members: (a) cell adhesion molecules, (b) signaling molecules, and (c) immune molecules expressed in the brain. The critical roles for IgSF members in regulating synapse formation may explain their extensive involvement in neuropsychiatric and neurodevelopmental disorders. Solving the IgSF code for synapse formation may reveal multiple new targets for rescuing IgSF-mediated deficits in synapse formation and, eventually, new treatments for psychiatric disorders caused by altered IgSF-induced synapse wiring.

Original languageEnglish (US)
Pages (from-to)567-590
Number of pages24
JournalAnnual Review of Genetics
Volume52
DOIs
StatePublished - Nov 23 2018

Fingerprint

Synapses
Immunoglobulins
Brain
Proteins
Immunoglobulin Isotypes
Cell Adhesion Molecules
Psychiatry
Vertebrates
Genome
Genes

Keywords

  • IgSF
  • immune molecules
  • immunoglobulin superfamily
  • LAR-RPTPs
  • MHCI molecules
  • synapse formation
  • synaptogenesis

ASJC Scopus subject areas

  • Genetics

Cite this

Immunoglobulin-like receptors and their impact on wiring of brain synapses. / Cameron, Scott; Usrey, A Kimberley.

In: Annual Review of Genetics, Vol. 52, 23.11.2018, p. 567-590.

Research output: Contribution to journalReview article

@article{49e7d4c52dca4848b081666737223b33,
title = "Immunoglobulin-like receptors and their impact on wiring of brain synapses",
abstract = "Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, focusing on examples from three classes of IgSF members: (a) cell adhesion molecules, (b) signaling molecules, and (c) immune molecules expressed in the brain. The critical roles for IgSF members in regulating synapse formation may explain their extensive involvement in neuropsychiatric and neurodevelopmental disorders. Solving the IgSF code for synapse formation may reveal multiple new targets for rescuing IgSF-mediated deficits in synapse formation and, eventually, new treatments for psychiatric disorders caused by altered IgSF-induced synapse wiring.",
keywords = "IgSF, immune molecules, immunoglobulin superfamily, LAR-RPTPs, MHCI molecules, synapse formation, synaptogenesis",
author = "Scott Cameron and Usrey, {A Kimberley}",
year = "2018",
month = "11",
day = "23",
doi = "10.1146/annurev-genet-120417-031513",
language = "English (US)",
volume = "52",
pages = "567--590",
journal = "Annual Review of Genetics",
issn = "0066-4197",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Immunoglobulin-like receptors and their impact on wiring of brain synapses

AU - Cameron, Scott

AU - Usrey, A Kimberley

PY - 2018/11/23

Y1 - 2018/11/23

N2 - Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, focusing on examples from three classes of IgSF members: (a) cell adhesion molecules, (b) signaling molecules, and (c) immune molecules expressed in the brain. The critical roles for IgSF members in regulating synapse formation may explain their extensive involvement in neuropsychiatric and neurodevelopmental disorders. Solving the IgSF code for synapse formation may reveal multiple new targets for rescuing IgSF-mediated deficits in synapse formation and, eventually, new treatments for psychiatric disorders caused by altered IgSF-induced synapse wiring.

AB - Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, focusing on examples from three classes of IgSF members: (a) cell adhesion molecules, (b) signaling molecules, and (c) immune molecules expressed in the brain. The critical roles for IgSF members in regulating synapse formation may explain their extensive involvement in neuropsychiatric and neurodevelopmental disorders. Solving the IgSF code for synapse formation may reveal multiple new targets for rescuing IgSF-mediated deficits in synapse formation and, eventually, new treatments for psychiatric disorders caused by altered IgSF-induced synapse wiring.

KW - IgSF

KW - immune molecules

KW - immunoglobulin superfamily

KW - LAR-RPTPs

KW - MHCI molecules

KW - synapse formation

KW - synaptogenesis

UR - http://www.scopus.com/inward/record.url?scp=85057241834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057241834&partnerID=8YFLogxK

U2 - 10.1146/annurev-genet-120417-031513

DO - 10.1146/annurev-genet-120417-031513

M3 - Review article

C2 - 30212237

AN - SCOPUS:85057241834

VL - 52

SP - 567

EP - 590

JO - Annual Review of Genetics

JF - Annual Review of Genetics

SN - 0066-4197

ER -