Immunoglobulin genes in autoimmunity

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The contribution of V germline genes and somatic mutation as well as the mechanism governing expression of the various V family genes in response to self-antigens are still unknown. Thus, we are still far from understanding the contribution and role of the B cell repertoire in human autoimmunity. Much of our current data on autoantibody gene repertoire are derived from laboratory generated hybridomas or animal model of autoimmune diseases. These may not reflect the human situation. In contrast, very few human autoantibodies with defined specificities have been structurally and genetically analyzed. In the future, meaningful data, perhaps from direct cloning and sequencing of autoantibodies derived from patients with autoimmune diseases, will be necessary to resolve issues in autoantibody repertoire usage. In this article, the prominent features of the human Ig repertoire, the usage of germline genes in autoantibodies, identifications of somatic mutations among autoantibodies and current data supporting either restricted or nonrestricted Ig gene usage and idiotypic expression among autoantibodies in several well-studied autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are discussed.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume101
Issue number2
StatePublished - 1993

Keywords

  • Autoimmune disease
  • Germline genes
  • Immunoglobulin repertoire
  • Restricted Ig variable gene usage
  • Somatic mutations

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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