Immunoglobulin G2 deficiency with transient hypogammaglobulinemia and chronic respiratory disease in a 6-month-old Holstein heifer

David Francoz, Jean Martin Lapointe, Vincent Wellemans, André Desrochers, Jeff L. Caswell, Jeffrey L Stott, Pascal Dubreuil

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 6-month-old Holstein heifer that was nonresponsive to medical treatment was evaluated for chronic respiratory disease. Complete blood count and serum chemistry revealed neutrophilic leukocytosis and low globulin levels. Assays for bovine leukemia virus, bovine virus diarrhea, and bovine leukocyte adhesion deficiency were negative. Serum globulin subclass assays revealed transient low concentrations of immunoglobulin (Ig) G1 and IgA, persistent low IgG2, and subnormal IgM. Vaccination with 2 doses of multiple, inactived viruses induced seroconversion for most viruses. Flow cytometric analysis of blood lymphocyte subpopulation demonstrated an increase in CD5+ B-cells. Blood lymphocyte proliferation and neutrophil function tests were normal. Results of immunologic assays indicated IgG2 deficiency with transient hypogammaglobulinemia.

Original languageEnglish (US)
Pages (from-to)432-435
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume16
Issue number5
StatePublished - Sep 2004

Fingerprint

Agammaglobulinemia
globulins
respiratory tract diseases
immunoglobulins
Immunoglobulins
heifers
Chronic Disease
Holstein
bovine leukocyte adhesion deficiency
Immunoglobulin G
Bovine Leukemia Virus
Viruses
Bovine Viral Diarrhea Viruses
Serum Globulins
Bovine leukemia virus
viruses
blood chemistry
bovine viral diarrhea
Blood Cell Count
hematologic tests

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Immunoglobulin G2 deficiency with transient hypogammaglobulinemia and chronic respiratory disease in a 6-month-old Holstein heifer. / Francoz, David; Lapointe, Jean Martin; Wellemans, Vincent; Desrochers, André; Caswell, Jeff L.; Stott, Jeffrey L; Dubreuil, Pascal.

In: Journal of Veterinary Diagnostic Investigation, Vol. 16, No. 5, 09.2004, p. 432-435.

Research output: Contribution to journalArticle

Francoz, David ; Lapointe, Jean Martin ; Wellemans, Vincent ; Desrochers, André ; Caswell, Jeff L. ; Stott, Jeffrey L ; Dubreuil, Pascal. / Immunoglobulin G2 deficiency with transient hypogammaglobulinemia and chronic respiratory disease in a 6-month-old Holstein heifer. In: Journal of Veterinary Diagnostic Investigation. 2004 ; Vol. 16, No. 5. pp. 432-435.
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