Immunoglobulin E responses and lung pathology resulting from aerosol exposure of calves to respiratory syncytial virus and Micropolyspora faeni

Laurel J Gershwin, D. L. Dungworth, S. R. Himes, K. E. Friebertshauser

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Abstract

Bovine respiratory syncytial virus (BRSV) infection of calves has been associated with a type-I hypersensitivity syndrome not unlike respiratory syncytial virus-associated pulmonary symptomatology in humans. To study the mechanism of pulmonary pathology in calves and define the relationship with both viral-specific IgE response and IgE titers to concurrent aerosol of Micropolyspora faeni (Mf) we subjected groups of calves to inhalation of Mf during acute BRSV infection. The calves were divided into 4 groups: exposed to virus only (group 1); exposed to aerosolized Mf over a 24-day period and then challenged with Mf during BRSV infection (group 2); similarly exposed to aerosolized Mf and then challenged with Mf without BRSV infection (group 3) and exposed to aerosolized Mf, infected with virus but not challenged with Mf (group 4). All calves were followed for appearance of IgE-specific responses to both BRSV and Mf, clinical disease expression, and pulmonary pathology including viral and allergen localization by immunohistology. Our data indicate an association of BRSV-specific IgE with increased development of lung pathology and clinical disease expression and an enhancing effect of aerosolized Mf on induction of virus-specific IgE. The presence of BRSV-specific IgE was solely in calves with the most significant macroscopic and microscopic pneumonic lesions.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalInternational Archives of Allergy and Applied Immunology
Volume92
Issue number3
StatePublished - 1990

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Nocardia
Respiratory Syncytial Viruses
Bovine respiratory syncytial virus
Aerosols
Immunoglobulin E
Pathology
Lung
Respiratory Syncytial Virus Infections
Viruses
Virus Activation
Immediate Hypersensitivity
Clinical Pathology
Allergens
Inhalation
Lung Diseases

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Immunoglobulin E responses and lung pathology resulting from aerosol exposure of calves to respiratory syncytial virus and Micropolyspora faeni. / Gershwin, Laurel J; Dungworth, D. L.; Himes, S. R.; Friebertshauser, K. E.

In: International Archives of Allergy and Applied Immunology, Vol. 92, No. 3, 1990, p. 293-300.

Research output: Contribution to journalArticle

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