TY - JOUR
T1 - Immunoglobulin E-mediated reactions to corticosteroids
AU - Cheam, Hay
AU - Butani, Lavjay
PY - 2005/1
Y1 - 2005/1
N2 - Allergic reactions to steroids are rare, but are becoming more commonly recognized by clinicians. Although many reactions are thought to be IgE mediated, most are adverse drug reactions caused by nonallergic mechanisms, some related to additives in the steroid preparation being administered. Provocative challenge with the suspected offending agent, serologic tests for allergen-specific IgE, and skin testing are the most reliable methods for assessing hypersensitivity to steroids, although none is infallible. Therapeutic options for patients with documented steroid allergy include the use of alternative steroid preparations, desensitization, and, possibly, the use of monoclonal anti-IgE antibodies.
AB - Allergic reactions to steroids are rare, but are becoming more commonly recognized by clinicians. Although many reactions are thought to be IgE mediated, most are adverse drug reactions caused by nonallergic mechanisms, some related to additives in the steroid preparation being administered. Provocative challenge with the suspected offending agent, serologic tests for allergen-specific IgE, and skin testing are the most reliable methods for assessing hypersensitivity to steroids, although none is infallible. Therapeutic options for patients with documented steroid allergy include the use of alternative steroid preparations, desensitization, and, possibly, the use of monoclonal anti-IgE antibodies.
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M3 - Article
C2 - 15659259
AN - SCOPUS:14644425913
VL - 5
SP - 22
EP - 27
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
SN - 1529-7322
IS - 1
ER -