Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle

F. Xusheng Lü, Zhongmin Ma, Tracy Rourke, Seema Srinivasan, Michael Mcchesney, Chris J Miller

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The levels of antigen-specific antibodies (Abs) and immunoglobulins in the cervical mucus of women vary with the menstrual cycle; the highest levels occur during menses, and the lowest occur during the periovulatory period. The rhesus macaque is a widely used animal model of female genital tract immunity. We sought to determine whether rhesus macaques have a cyclical pattern of changing cervicovaginal Ab and immunoglobulin levels that is similar to that of the human female. This study examined the relationship of the stages of the menstrual cycle to genital mucosal and systemic immunoglobulin concentrations and Ab levels in rhesus macaques. In all seven rhesus macaques studied, the immunoglobulins G and A and some antibodies in cervicovaginal lavages varied with the stages of the menstrual cycle, and in many cases this variation reached the level of statistical significance. In a pattern similar to that of women, the highest levels of Abs and immunoglobulins occurred during menses, and the lowest levels occurred around the time of ovulation. However, the Ab and immunoglobulin levels in serum and rectal lavages did not change with the menstrual cycle stage. The results of this study are consistent with the hypothesis that the ovarian hormones that drive the menstrual cycle influence genital tract immunity in female primates.

Original languageEnglish (US)
Pages (from-to)6321-6328
Number of pages8
JournalInfection and Immunity
Volume67
Issue number12
StatePublished - Dec 1999

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Therapeutic Irrigation
Menstrual Cycle
Macaca mulatta
Immunoglobulins
Antigens
Antibodies
Menstruation
Immunity
Cervix Mucus
Ovulation
Immunoglobulin A
Primates
Animal Models
Immunoglobulin G
Hormones
Serum

ASJC Scopus subject areas

  • Immunology

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Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle. / Lü, F. Xusheng; Ma, Zhongmin; Rourke, Tracy; Srinivasan, Seema; Mcchesney, Michael; Miller, Chris J.

In: Infection and Immunity, Vol. 67, No. 12, 12.1999, p. 6321-6328.

Research output: Contribution to journalArticle

Lü, F. Xusheng ; Ma, Zhongmin ; Rourke, Tracy ; Srinivasan, Seema ; Mcchesney, Michael ; Miller, Chris J. / Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle. In: Infection and Immunity. 1999 ; Vol. 67, No. 12. pp. 6321-6328.
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