Abstract
The 'classical' myelin basic protein (MBP) exons belong to a much larger unit, termed the 'Golli-MBP' gene. Here we have examined the T-cell determinant structure of the Golli protein region in the BALB/c mouse. Golli p10-24, which was shown to have the strongest affinity for I-A(d), could not induce T-cell activation. Paradoxically, the poorer binding, overlapping p5-19 was effective at inducing T-cell proliferation. Thus, immunogenicity is not necessarily related to the MHC-binding affinity of self-peptides. In addition, MBP: p151-168-specific T cell clones responded only poorly to J37, a Golli-MBP protein, while MBP: 59-76-specific clones responded well to J37. (C) 2000 Academic Press.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-322 |
| Number of pages | 8 |
| Journal | Journal of Autoimmunity |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2000 |
Keywords
- Autoimmunity
- Golli-MBP
- MHC binding affinity
- Self antigen
- Tolerance
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Fingerprint Dive into the research topics of 'Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse'. Together they form a unique fingerprint.
Cite this
Maverakis, E. M., Mendoza, R., Southwood, S., Raja-Gabaglia, C., Abromson-Leeman, S., Campagnoni, A. T., Sette, A., & Sercarz, E. E. (2000). Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse. Journal of Autoimmunity, 15(3), 315-322. https://doi.org/10.1006/jaut.2000.0436