Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse

Emanual Michael Maverakis, Richard Mendoza, Scott Southwood, Claudia Raja-Gabaglia, Sara Abromson-Leeman, Anthony T. Campagnoni, Alessandro Sette, Eli E. Sercarz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The 'classical' myelin basic protein (MBP) exons belong to a much larger unit, termed the 'Golli-MBP' gene. Here we have examined the T-cell determinant structure of the Golli protein region in the BALB/c mouse. Golli p10-24, which was shown to have the strongest affinity for I-A(d), could not induce T-cell activation. Paradoxically, the poorer binding, overlapping p5-19 was effective at inducing T-cell proliferation. Thus, immunogenicity is not necessarily related to the MHC-binding affinity of self-peptides. In addition, MBP: p151-168-specific T cell clones responded only poorly to J37, a Golli-MBP protein, while MBP: 59-76-specific clones responded well to J37. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)315-322
Number of pages8
JournalJournal of Autoimmunity
Volume15
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Autoimmunity
  • Golli-MBP
  • MHC binding affinity
  • Self antigen
  • Tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Maverakis, E. M., Mendoza, R., Southwood, S., Raja-Gabaglia, C., Abromson-Leeman, S., Campagnoni, A. T., Sette, A., & Sercarz, E. E. (2000). Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse. Journal of Autoimmunity, 15(3), 315-322. https://doi.org/10.1006/jaut.2000.0436