TY - JOUR
T1 - Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein
AU - Feng, Sunlian
AU - Hodzic, Emir
AU - Freet, Kimberly
AU - Barthold, Stephen W
PY - 2003/12
Y1 - 2003/12
N2 - Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
AB - Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
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U2 - 10.1128/IAI.71.12.7211-7214.2003
DO - 10.1128/IAI.71.12.7211-7214.2003
M3 - Article
C2 - 14638819
AN - SCOPUS:0345283030
VL - 71
SP - 7211
EP - 7214
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 12
ER -