Abstract
Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7211-7214 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 71 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2003 |
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ASJC Scopus subject areas
- Immunology
Cite this
Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein. / Feng, Sunlian; Hodzic, Emir; Freet, Kimberly; Barthold, Stephen W.
In: Infection and Immunity, Vol. 71, No. 12, 12.2003, p. 7211-7214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein
AU - Feng, Sunlian
AU - Hodzic, Emir
AU - Freet, Kimberly
AU - Barthold, Stephen W
PY - 2003/12
Y1 - 2003/12
N2 - Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
AB - Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
UR - http://www.scopus.com/inward/record.url?scp=0345283030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345283030&partnerID=8YFLogxK
U2 - 10.1128/IAI.71.12.7211-7214.2003
DO - 10.1128/IAI.71.12.7211-7214.2003
M3 - Article
C2 - 14638819
AN - SCOPUS:0345283030
VL - 71
SP - 7211
EP - 7214
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 12
ER -