Abstract
Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7211-7214 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 71 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2003 |
ASJC Scopus subject areas
- Immunology
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Cite this
Feng, S., Hodzic, E., Freet, K., & Barthold, S. W. (2003). Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein. Infection and Immunity, 71(12), 7211-7214. https://doi.org/10.1128/IAI.71.12.7211-7214.2003