Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein

Sunlian Feng, Emir Hodzic, Kimberly Freet, Stephen W Barthold

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.

Original languageEnglish (US)
Pages (from-to)7211-7214
Number of pages4
JournalInfection and Immunity
Volume71
Issue number12
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein'. Together they form a unique fingerprint.

  • Cite this