Immunodeficient mice as models of human hematapoietic stem cell engraftment

Mo A. Dao, Jan Nolta

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The past year has brought forth some exciting developments in the use of murine xenotransplantation systems to study the biology and transduction of human hematopoietic stem cells. The effects of cytokines have been studied by injection into the mice or by treatment of the cell inoculum prior to injection. The importance of the cell cycle and integrin expression has been evaluated. New methods of gene therapy have been tested in xenograft models - including cell cycle manipulation and a promising new lentiviral vector system, based on HIV.

Original languageEnglish (US)
Pages (from-to)532-537
Number of pages6
JournalCurrent Opinion in Immunology
Volume11
Issue number5
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

Fingerprint

Cell Cycle
Stem Cells
Heterologous Transplantation
Injections
Hematopoietic Stem Cells
Heterografts
Integrins
Genetic Therapy
HIV
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunodeficient mice as models of human hematapoietic stem cell engraftment. / Dao, Mo A.; Nolta, Jan.

In: Current Opinion in Immunology, Vol. 11, No. 5, 01.10.1999, p. 532-537.

Research output: Contribution to journalArticle

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