Abstract
The Mason-Pfizer monkey virus (MPMV) was reisolated from a cryopreserved sample of the original MPMV-containing rhesus breast carcinoma, and complete integrated MPMV pro-virus was detected in chromosomal DNA of this tumor. Reanalysis of the in vivo pathogenicity and molecular character of MPMV reisolated from the rhesus breast tumor and analysis of the original MPMV after long-term in vitro propagation in human and rhesus cells show that 1) the original MPMV produces an acquired immunodeficiency similar to that caused by the recently described simian acquired immune deficiency syndrome type D retroviruses, and 2) the MPMV genome and its immunosuppressive effect in vivo have remained stable despite prolonged in vitro passage in human and rhesus cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 957-965 |
| Number of pages | 9 |
| Journal | Journal of the National Cancer Institute |
| Volume | 77 |
| Issue number | 4 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Immunodeficiency in Rhesus monkeys associated with the original Mason-Pfizer monkey virus. / Bryant, M. L.; Gardner, M. B.; Marx, P. A.; Maul, D. H.; Lerche, N. W.; Osborn, K. G.; Lowenstine, L. J.; Bodgen, A.; Arthur, L. O.; Hunter, E.
In: Journal of the National Cancer Institute, Vol. 77, No. 4, 1986, p. 957-965.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunodeficiency in Rhesus monkeys associated with the original Mason-Pfizer monkey virus
AU - Bryant, M. L.
AU - Gardner, M. B.
AU - Marx, P. A.
AU - Maul, D. H.
AU - Lerche, N. W.
AU - Osborn, K. G.
AU - Lowenstine, L. J.
AU - Bodgen, A.
AU - Arthur, L. O.
AU - Hunter, E.
PY - 1986
Y1 - 1986
N2 - The Mason-Pfizer monkey virus (MPMV) was reisolated from a cryopreserved sample of the original MPMV-containing rhesus breast carcinoma, and complete integrated MPMV pro-virus was detected in chromosomal DNA of this tumor. Reanalysis of the in vivo pathogenicity and molecular character of MPMV reisolated from the rhesus breast tumor and analysis of the original MPMV after long-term in vitro propagation in human and rhesus cells show that 1) the original MPMV produces an acquired immunodeficiency similar to that caused by the recently described simian acquired immune deficiency syndrome type D retroviruses, and 2) the MPMV genome and its immunosuppressive effect in vivo have remained stable despite prolonged in vitro passage in human and rhesus cells.
AB - The Mason-Pfizer monkey virus (MPMV) was reisolated from a cryopreserved sample of the original MPMV-containing rhesus breast carcinoma, and complete integrated MPMV pro-virus was detected in chromosomal DNA of this tumor. Reanalysis of the in vivo pathogenicity and molecular character of MPMV reisolated from the rhesus breast tumor and analysis of the original MPMV after long-term in vitro propagation in human and rhesus cells show that 1) the original MPMV produces an acquired immunodeficiency similar to that caused by the recently described simian acquired immune deficiency syndrome type D retroviruses, and 2) the MPMV genome and its immunosuppressive effect in vivo have remained stable despite prolonged in vitro passage in human and rhesus cells.
UR - http://www.scopus.com/inward/record.url?scp=0022538424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022538424&partnerID=8YFLogxK
M3 - Article
C2 - 3020302
AN - SCOPUS:0022538424
VL - 77
SP - 957
EP - 965
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 4
ER -