Abstract
The distribution of mouse mammary tumor virus (MuMTV) antigens was studied in normal, preneoplastlc, and neoplastic mammary eplthelia from female BALB/cfC3H mice with the use of a polyvalent anti-MuMTV serum and indirect Immunoperoxidase techniques. The MuMTV antigens were on the apical surface or in focal cytoplasmic aggregates or diffused throughout the infected cells. As much as 70% of all cells in adenocarcinomas and as much as 100% of all cells in preneoplastlc hyperplastic alveolar nodules contained MuMTV antigens. Comparable percentages of cells from mammary glands of multl-parous mice were MuMTV-positlve. Some mammary tissues of nulliparous and primiparous mice did not contain detectable MuMTV antigen. The MuMTV antigen-containing cells In lactat-Ing mammary glands tended to be in discrete lobuloalveolar clusters surrounded by antigen-negative alveoli. The percentage of MuMTV-positlve cells in a given gland was proportional to the amount of virus found in the animal’s milk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 813-820 |
| Number of pages | 8 |
| Journal | Journal of the National Cancer Institute |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1979 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
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Immunocytochemical distribution of mouse mammary tumor virus antigens in BALB/cfC3H mammary epithelium. / St. George, Judith A.; Cardiff, Robert; Young, Lawrence J.T.; Faulkin, Leslie J.
In: Journal of the National Cancer Institute, Vol. 63, No. 3, 01.01.1979, p. 813-820.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunocytochemical distribution of mouse mammary tumor virus antigens in BALB/cfC3H mammary epithelium
AU - St. George, Judith A.
AU - Cardiff, Robert
AU - Young, Lawrence J.T.
AU - Faulkin, Leslie J.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The distribution of mouse mammary tumor virus (MuMTV) antigens was studied in normal, preneoplastlc, and neoplastic mammary eplthelia from female BALB/cfC3H mice with the use of a polyvalent anti-MuMTV serum and indirect Immunoperoxidase techniques. The MuMTV antigens were on the apical surface or in focal cytoplasmic aggregates or diffused throughout the infected cells. As much as 70% of all cells in adenocarcinomas and as much as 100% of all cells in preneoplastlc hyperplastic alveolar nodules contained MuMTV antigens. Comparable percentages of cells from mammary glands of multl-parous mice were MuMTV-positlve. Some mammary tissues of nulliparous and primiparous mice did not contain detectable MuMTV antigen. The MuMTV antigen-containing cells In lactat-Ing mammary glands tended to be in discrete lobuloalveolar clusters surrounded by antigen-negative alveoli. The percentage of MuMTV-positlve cells in a given gland was proportional to the amount of virus found in the animal’s milk.
AB - The distribution of mouse mammary tumor virus (MuMTV) antigens was studied in normal, preneoplastlc, and neoplastic mammary eplthelia from female BALB/cfC3H mice with the use of a polyvalent anti-MuMTV serum and indirect Immunoperoxidase techniques. The MuMTV antigens were on the apical surface or in focal cytoplasmic aggregates or diffused throughout the infected cells. As much as 70% of all cells in adenocarcinomas and as much as 100% of all cells in preneoplastlc hyperplastic alveolar nodules contained MuMTV antigens. Comparable percentages of cells from mammary glands of multl-parous mice were MuMTV-positlve. Some mammary tissues of nulliparous and primiparous mice did not contain detectable MuMTV antigen. The MuMTV antigen-containing cells In lactat-Ing mammary glands tended to be in discrete lobuloalveolar clusters surrounded by antigen-negative alveoli. The percentage of MuMTV-positlve cells in a given gland was proportional to the amount of virus found in the animal’s milk.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018711154&partnerID=8YFLogxK
U2 - 10.1093/jnci/63.3.813
DO - 10.1093/jnci/63.3.813
M3 - Article
C2 - 224238
AN - SCOPUS:0018711154
VL - 63
SP - 813
EP - 820
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -