TY - JOUR
T1 - Immunocytochemical distribution of mouse mammary tumor virus antigens in BALB/cfC3H mammary epithelium
AU - St. George, Judith A.
AU - Cardiff, Robert
AU - Young, Lawrence J.T.
AU - Faulkin, Leslie J.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The distribution of mouse mammary tumor virus (MuMTV) antigens was studied in normal, preneoplastlc, and neoplastic mammary eplthelia from female BALB/cfC3H mice with the use of a polyvalent anti-MuMTV serum and indirect Immunoperoxidase techniques. The MuMTV antigens were on the apical surface or in focal cytoplasmic aggregates or diffused throughout the infected cells. As much as 70% of all cells in adenocarcinomas and as much as 100% of all cells in preneoplastlc hyperplastic alveolar nodules contained MuMTV antigens. Comparable percentages of cells from mammary glands of multl-parous mice were MuMTV-positlve. Some mammary tissues of nulliparous and primiparous mice did not contain detectable MuMTV antigen. The MuMTV antigen-containing cells In lactat-Ing mammary glands tended to be in discrete lobuloalveolar clusters surrounded by antigen-negative alveoli. The percentage of MuMTV-positlve cells in a given gland was proportional to the amount of virus found in the animal’s milk.
AB - The distribution of mouse mammary tumor virus (MuMTV) antigens was studied in normal, preneoplastlc, and neoplastic mammary eplthelia from female BALB/cfC3H mice with the use of a polyvalent anti-MuMTV serum and indirect Immunoperoxidase techniques. The MuMTV antigens were on the apical surface or in focal cytoplasmic aggregates or diffused throughout the infected cells. As much as 70% of all cells in adenocarcinomas and as much as 100% of all cells in preneoplastlc hyperplastic alveolar nodules contained MuMTV antigens. Comparable percentages of cells from mammary glands of multl-parous mice were MuMTV-positlve. Some mammary tissues of nulliparous and primiparous mice did not contain detectable MuMTV antigen. The MuMTV antigen-containing cells In lactat-Ing mammary glands tended to be in discrete lobuloalveolar clusters surrounded by antigen-negative alveoli. The percentage of MuMTV-positlve cells in a given gland was proportional to the amount of virus found in the animal’s milk.
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U2 - 10.1093/jnci/63.3.813
DO - 10.1093/jnci/63.3.813
M3 - Article
C2 - 224238
AN - SCOPUS:0018711154
VL - 63
SP - 813
EP - 820
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -