Immunobiology of T Cells in Sjögren’s Syndrome

Yuan Yao, Jin Fen Ma, Christopher Chang, Ting Xu, Cai Yue Gao, M. Eric Gershwin, Zhe Xiong Lian

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Sjögren’s syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its pathogenesis involves an inflammatory process that is characterized by lymphocytic infiltration into exocrine glands and other tissues. Although the development of ectopic lymphoid tissue and overproduction of autoantibodies by hyperactive B cells suggest that they may promote SjS development, treatment directed towards them fails to induce significant laboratory or clinical improvement. T cells are overwhelming infiltrators in most phases of the disease, and the involvement of multiple T cell subsets of suggests the extraordinary complexity of SjS pathogenesis. The factors, including various cellular subtypes and molecules, regulate the activation and suppression of T cells. T cell activation induces inflammatory cell infiltration, B cell activation, tissue damage, and metabolic changes in SjS. Knowledge of the pathways that link these T cell subtypes and regulation of their activities are not completely understood. This review comprehensively summarizes the research progress and our understanding of T cells in SjS, including CD4+ T cells, CD8+ TRM cells, and innate T cells, to provide insights into for clinical treatment.

Original languageEnglish (US)
JournalClinical Reviews in Allergy and Immunology
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • Clinical treatment
  • Pathogenic roles
  • Sjögren’s syndrome
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy

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