Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides

Ki Chang Ahn, Hee Joo Kim, Mark R. McCoy, Shirley J. Gee, Bruce D. Hammock

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

This paper describes some of the early work on pyrethroid insecticides in the Casida laboratory and briefly reviews the development and application of immunochemical approaches for the detection of pyrethroid insecticides and their metabolites for monitoring environmental and human exposure. Multiple technologies can be combined to enhance the sensitivity and speed of immunochemical analysis. The pyrethroid assays are used to illustrate the use of some of these immunoreagents such as antibodies, competitive mimics, and novel binding agents such as phage-displayed peptides. The paper also illustrates reporters such as fluorescent dyes, chemiluminescent compounds, and luminescent lanthanide nanoparticles, as well as the application of magnetic separation, and automatic instrumental systems, biosensors, and novel immunological technologies. These new technologies alone and in combination result in an improved ability to both determine if effective levels of pyrethroids are being used in the field and evaluate possible contamination.

Original languageEnglish (US)
Pages (from-to)2792-2802
Number of pages11
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number7
DOIs
StatePublished - Apr 13 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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