Immunization of chickens with temperature-sensitive mutants of Mycoplasma gallisepticum.

K. M. Lam, W. Q. Lin, R. Yamamoto, T. B. Farver

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Temperature-sensitive (TS) mutants of the S6 strain of Mycoplasma gallisepticum (MG) were used to immunize newly hatched chickens. Immunized chickens developed antibodies to the wild-type (WT) S6 strain as demonstrated by serologic tests. MG was recovered from nasal cavities but not from the lower respiratory tract of the immunized chicks. Three weeks after intranasal immunization, chickens were challenged via the air sacs with the virulent S6 strain. Immunized chickens were significantly better protected from development of air-sac lesions than were controls.

Original languageEnglish (US)
Pages (from-to)803-812
Number of pages10
JournalAvian Diseases
Issue number3
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Cancer Research


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