Immunization against the agent of human granulocytic ehrlichiosis in a murine model

Wei Sun, Jacob W. Ijdo, Sam R. Telford, Emir Hodzic, Yan Zhang, Stephen W Barthold, Erol Fikrig

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

Original languageEnglish (US)
Pages (from-to)3014-3018
Number of pages5
JournalJournal of Clinical Investigation
Volume100
Issue number12
StatePublished - Dec 15 1997
Externally publishedYes

Fingerprint

Ehrlichiosis
Immunization
Syringes
Ticks
Immunity
Tick-Borne Diseases
Inbred C3H Mouse
Neutropenia
Immune Sera
Neutrophils
Antibodies

Keywords

  • Antibody
  • Ehrlichia
  • Intracellular pathogen
  • Ticks
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunization against the agent of human granulocytic ehrlichiosis in a murine model. / Sun, Wei; Ijdo, Jacob W.; Telford, Sam R.; Hodzic, Emir; Zhang, Yan; Barthold, Stephen W; Fikrig, Erol.

In: Journal of Clinical Investigation, Vol. 100, No. 12, 15.12.1997, p. 3014-3018.

Research output: Contribution to journalArticle

Sun, W, Ijdo, JW, Telford, SR, Hodzic, E, Zhang, Y, Barthold, SW & Fikrig, E 1997, 'Immunization against the agent of human granulocytic ehrlichiosis in a murine model', Journal of Clinical Investigation, vol. 100, no. 12, pp. 3014-3018.
Sun, Wei ; Ijdo, Jacob W. ; Telford, Sam R. ; Hodzic, Emir ; Zhang, Yan ; Barthold, Stephen W ; Fikrig, Erol. / Immunization against the agent of human granulocytic ehrlichiosis in a murine model. In: Journal of Clinical Investigation. 1997 ; Vol. 100, No. 12. pp. 3014-3018.
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