Immunization against the agent of human granulocytic ehrlichiosis in a murine model

Wei Sun, Jacob W. Ijdo, Sam R. Telford, Emir Hodzic, Yan Zhang, Stephen W Barthold, Erol Fikrig

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

Original languageEnglish (US)
Pages (from-to)3014-3018
Number of pages5
JournalJournal of Clinical Investigation
Volume100
Issue number12
StatePublished - Dec 15 1997
Externally publishedYes

Keywords

  • Antibody
  • Ehrlichia
  • Intracellular pathogen
  • Ticks
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)

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