Immunity to Rhodococcus equi

S. A. Hines, S. T. Kanaly, Barbara A Byrne, G. H. Palmer

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Rhodococcal pneumonia is an important, life threatening disease of foals and immunosuppressed humans. Increased knowledge of the mechanisms of protective immunity are required in order to develop an effective immunoprophylaxis strategy for horses and immunotherapeutic regiments for people. Both humoral and cellular components of the immune system may be involved in immune clearance of R. equi. The susceptibility of foals less than 4-6 months of age is postulated to reflect waning maternal antibody, and passive transfer of hyperimmune plasma can provide protection on endemic farms. However, effective clearance is likely to require appropriate cellular responses, including the secretion of cytokines. In murine models, both CD4 + and CD8 + T lymphocytes can reduce bacterial counts in the lung. CD4 + cells appear to be both required and sufficient, and IFN-gamma is a primary mediator. Clearance appears to be a type 1 immune response while type 2 responses may lead to a failure to clear and lesion development. It remains to be determined how the cellular immunity experiments reported in mice relate to horses and humans. Likewise, the role of specific R. equi antigens in protective immunity has not been determined.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalVeterinary Microbiology
Volume56
Issue number3-4
DOIs
StatePublished - Jun 16 1997
Externally publishedYes

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Keywords

  • Pulmonary immunity
  • Review
  • Rhodococcus equi
  • Th1 immunity

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

Hines, S. A., Kanaly, S. T., Byrne, B. A., & Palmer, G. H. (1997). Immunity to Rhodococcus equi. Veterinary Microbiology, 56(3-4), 177-185. https://doi.org/10.1016/S0378-1135(97)00086-2