Immunity to infections in the lower genital tract of bulls

Eduardo R. Cobo, Lynette B. Corbeil, Robert Bondurant

Research output: Contribution to journalReview article

13 Scopus citations


The mucosa of the bovine prepuce has unique immunological characteristics critical to defense against sexually transmitted diseases. Tritrichomonas foetus and Campylobacter fetus subspecies venerealis persistently colonize the lower genital tract of bulls but usually do not cause either major clinical signs or inflammation. These microbes may be sexually transmitted to female cattle to cause reproductive failure. Although the male genital immune responses to T. foetus and C. fetus subspecies venerealis are inefficient in clearing infection, systemic immunization with T. foetus and C. fetus subspecies venerealis antigens does prevent or eliminate these infections with induction of IgG antibodies in genital secretions and serum.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of Reproductive Immunology
Issue number1
StatePublished - Apr 1 2011



  • Bovine sexually transmitted disease
  • Campylobacter fetus subsp. venerealis
  • Male immunity
  • Tritrichomonas foetus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

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