Immunity targeting common core antigens of gram-negative bacteria.

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30 Scopus citations


Antibodies against common gram-negative core antigens can provide protection against environmental, commensual, and contagious bacteria that cause life-threatening gram-negative sepsis/endotoxemia. Cross-protective immunity may be effective against many common livestock diseases, including neonatal coliform septicemia, coliform mastitis, septic metritis, and severe enteritis. The greatest potential benefit of cross-protective immunity may be realized in the reduction of ill-thrift and mortality of neonates. The use of active and passive immunization against core antigens common to gram-negative bacteria has been successful in human beings, laboratory animals, and livestock. Protection has been observed following challenge with either heterologous endotoxin or unrelated, live, virulent gram-negative bacteria.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Issue number1
StatePublished - Jan 1990

ASJC Scopus subject areas

  • veterinary(all)


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