Immune responses to Neospora caninum and prospects for vaccination

Elisabeth A. Innes, Aurélie G. Andrianarivo, Camilla Björkman, Diana J L Williams, Patricia A Conrad

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

Developing an effective vaccine against neosporosis presents several interesting challenges. The parasite is spread efficiently from mother to foetus over several generations, and naturally infected cattle do not appear to develop adequate protective immunity. Modulation of the immune response during pregnancy favours parasite survival and multiplication. However, induction of pro-inflammatory responses that are thought to be protective against Neospora caninum would be detrimental to the pregnancy. So, is vaccination a feasible option to control the disease? This article discusses some of these issues and reports on the progress towards a vaccine for neosporosis.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalTrends in Parasitology
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2002

Keywords

  • Abortion
  • Cattle
  • Immune responses
  • Immunology
  • Neospora caninum
  • Parasitology
  • Pharmaceutical Science
  • Vaccination

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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