Immune response and immunotherapy to Cryptococcus infections

Qing Zhou; William J Murphy

doi:10.1385/IR:35:3:191

Immune response and immunotherapy to Cryptococcus infections

Qing Zhou, William J Murphy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.

Original language	English (US)
Pages (from-to)	191-207
Number of pages	17
Journal	Immunologic Research
Volume	35
Issue number	3
DOIs	https://doi.org/10.1385/IR:35:3:191
State	Published - Jul 2006
Externally published	Yes

Keywords

Anti-CD40
Cryptococcus neoformans
Immune response
Immunotherapy
Interleukin-2

ASJC Scopus subject areas

Immunology

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10.1385/IR:35:3:191

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AB - Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.

KW - Anti-CD40

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KW - Immune response

KW - Immunotherapy

KW - Interleukin-2

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Immune response and immunotherapy to Cryptococcus infections

Abstract

Keywords

ASJC Scopus subject areas

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