Abstract
Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-207 |
| Number of pages | 17 |
| Journal | Immunologic Research |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2006 |
| Externally published | Yes |
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Keywords
- Anti-CD40
- Cryptococcus neoformans
- Immune response
- Immunotherapy
- Interleukin-2
ASJC Scopus subject areas
- Immunology
Cite this
Immune response and immunotherapy to Cryptococcus infections. / Zhou, Qing; Murphy, William J.
In: Immunologic Research, Vol. 35, No. 3, 07.2006, p. 191-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune response and immunotherapy to Cryptococcus infections
AU - Zhou, Qing
AU - Murphy, William J
PY - 2006/7
Y1 - 2006/7
N2 - Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.
AB - Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.
KW - Anti-CD40
KW - Cryptococcus neoformans
KW - Immune response
KW - Immunotherapy
KW - Interleukin-2
UR - http://www.scopus.com/inward/record.url?scp=33845869565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845869565&partnerID=8YFLogxK
U2 - 10.1385/IR:35:3:191
DO - 10.1385/IR:35:3:191
M3 - Article
C2 - 17172646
AN - SCOPUS:33845869565
VL - 35
SP - 191
EP - 207
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 3
ER -