Immune response and immunotherapy to Cryptococcus infections

Qing Zhou, William J Murphy

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.

Original languageEnglish (US)
Pages (from-to)191-207
Number of pages17
JournalImmunologic Research
Issue number3
StatePublished - Jul 2006
Externally publishedYes


  • Anti-CD40
  • Cryptococcus neoformans
  • Immune response
  • Immunotherapy
  • Interleukin-2

ASJC Scopus subject areas

  • Immunology


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