Immune regulation of bone loss by Th17 cells

Iannis Adamopoulos; Edward P. Bowman

doi:10.1186/ar2502

Immune regulation of bone loss by Th17 cells

Iannis Adamopoulos, Edward P. Bowman

Research output: Contribution to journal › Article

47 Scopus citations

Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

Original language	English (US)
Article number	225
Journal	Arthritis Research and Therapy
Volume	10
Issue number	5
DOIs	https://doi.org/10.1186/ar2502
State	Published - Oct 17 2008
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Immunology
Immunology and Allergy
Medicine(all)

Access to Document

10.1186/ar2502

Fingerprint Dive into the research topics of 'Immune regulation of bone loss by Th17 cells'. Together they form a unique fingerprint.

Cite this

Adamopoulos, I., & Bowman, E. P. (2008). Immune regulation of bone loss by Th17 cells. Arthritis Research and Therapy, 10(5), [225]. https://doi.org/10.1186/ar2502

@article{662a52251f4043c6a1f3e295149acc85,

title = "Immune regulation of bone loss by Th17 cells",

abstract = "A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.",

author = "Iannis Adamopoulos and Bowman, {Edward P.}",

year = "2008",

month = oct,

day = "17",

doi = "10.1186/ar2502",

language = "English (US)",

volume = "10",

journal = "Arthritis Research and Therapy",

issn = "1478-6354",

publisher = "BioMed Central",

number = "5",

}

TY - JOUR

T1 - Immune regulation of bone loss by Th17 cells

AU - Adamopoulos, Iannis

AU - Bowman, Edward P.

PY - 2008/10/17

Y1 - 2008/10/17

N2 - A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

AB - A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

UR - http://www.scopus.com/inward/record.url?scp=60549110257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549110257&partnerID=8YFLogxK

U2 - 10.1186/ar2502

DO - 10.1186/ar2502

M3 - Article

C2 - 18983698

AN - SCOPUS:60549110257

VL - 10

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

SN - 1478-6354

IS - 5

M1 - 225

ER -