Immune regulation of bone loss by Th17 cells

Iannis Adamopoulos, Edward P. Bowman

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

Original languageEnglish (US)
Article number225
JournalArthritis Research and Therapy
Issue number5
StatePublished - Oct 17 2008
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)


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