Immune regulation of bone loss by Th17 cells

Iannis Adamopoulos; Edward P. Bowman

doi:10.1186/ar2502

Immune regulation of bone loss by Th17 cells

Iannis Adamopoulos, Edward P. Bowman

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

Original language	English (US)
Article number	225
Journal	Arthritis Research and Therapy
Volume	10
Issue number	5
DOIs	https://doi.org/10.1186/ar2502
State	Published - Oct 17 2008
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Immunology
Immunology and Allergy
Medicine(all)

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Immune regulation of bone loss by Th17 cells

Abstract

ASJC Scopus subject areas

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