Abstract
An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1162-1165 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 20 |
| Issue number | 6 |
| State | Published - 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
Immune regulation by lipids. / Perez, Richard V; Alexander, J. W.
In: Transplantation Proceedings, Vol. 20, No. 6, 1988, p. 1162-1165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune regulation by lipids
AU - Perez, Richard V
AU - Alexander, J. W.
PY - 1988
Y1 - 1988
N2 - An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.
AB - An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024208835&partnerID=8YFLogxK
M3 - Article
C2 - 3059600
AN - SCOPUS:0024208835
VL - 20
SP - 1162
EP - 1165
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 6
ER -