Immune regulation by lipids

Richard V Perez, J. W. Alexander

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.

Original languageEnglish (US)
Pages (from-to)1162-1165
Number of pages4
JournalTransplantation Proceedings
Volume20
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Lipids
Diet
Mononuclear Phagocyte System
Immunosuppressive Agents
Humoral Immunity
Cellular Immunity
Autoimmune Diseases
Immune System
Sepsis
Transplantation
Fats
Cell Membrane
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Perez, R. V., & Alexander, J. W. (1988). Immune regulation by lipids. Transplantation Proceedings, 20(6), 1162-1165.

Immune regulation by lipids. / Perez, Richard V; Alexander, J. W.

In: Transplantation Proceedings, Vol. 20, No. 6, 1988, p. 1162-1165.

Research output: Contribution to journalArticle

Perez, RV & Alexander, JW 1988, 'Immune regulation by lipids', Transplantation Proceedings, vol. 20, no. 6, pp. 1162-1165.
Perez, Richard V ; Alexander, J. W. / Immune regulation by lipids. In: Transplantation Proceedings. 1988 ; Vol. 20, No. 6. pp. 1162-1165.
@article{84adb5b350834d3489a0bfafd2ac5e41,
title = "Immune regulation by lipids",
abstract = "An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.",
author = "Perez, {Richard V} and Alexander, {J. W.}",
year = "1988",
language = "English (US)",
volume = "20",
pages = "1162--1165",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Immune regulation by lipids

AU - Perez, Richard V

AU - Alexander, J. W.

PY - 1988

Y1 - 1988

N2 - An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.

AB - An abundance of evidence supports the role of dietary lipids as regulators of the immune system. This is demonstrated by studies examining lipid alteration of the immune response to malignancy, autoimmune disease, sepsis, trauma, and transplantation. Both the quantity and quality of lipid is important in immunoregulation. In general, high-lipid diets are immunosuppressive. PUFA diets tend to be more suppressive than saturated-fat diets, though recent evidence suggests that the omega-3 PUFA have immunostimulatory properties. Both cell-mediated and humoral immunity are affected by dietary lipids. Multiple mechanisms are likely contributing to the overall effects of lipids, including alteration of AA metabolism, changes in cell membranes, and impairment of the reticuloendothelial system. As continuing progress is made in clinical interventions to regulate the immune response, it has become necessary to consider the role of dietary lipids in this setting.

UR - http://www.scopus.com/inward/record.url?scp=0024208835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024208835&partnerID=8YFLogxK

M3 - Article

C2 - 3059600

AN - SCOPUS:0024208835

VL - 20

SP - 1162

EP - 1165

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 6

ER -