Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates

A. Lazo, R. T. Bailer, J. R. Blakeslee, R. Yanagihara, V. C. Stevens, L. Kramer, Michael Dale Lairmore

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nucleotide sequence analysis of selected regions of the gag, pol, env and pX genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that African isolates were more closely related to human T-cell lymphotropic virus type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition of distinct STLV-I strains. In this study, we demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that the baboon virus isolates were more closely related to HTLV-I than the Japanese isolates. These results indicate that nucleotide sequence diversity, correlates with variations in proviral restriction enzyme sites and antibody recognition of viral envelope proteins. These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection.

Original languageEnglish (US)
Pages (from-to)307-323
Number of pages17
JournalArchives of Virology
Volume140
Issue number2
DOIs
StatePublished - Feb 1995
Externally publishedYes

Fingerprint

Simian T-lymphotropic virus 1
T-Lymphocytes
Viruses
Papio cynocephalus
Macaca
pX Genes
pol Genes
gag Genes
Viral Envelope Proteins
env Genes
Restriction Mapping
Antibodies
Papio
Virus Diseases
Sequence Homology
Serum

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

Cite this

Lazo, A., Bailer, R. T., Blakeslee, J. R., Yanagihara, R., Stevens, V. C., Kramer, L., & Lairmore, M. D. (1995). Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. Archives of Virology, 140(2), 307-323. https://doi.org/10.1007/BF01309864

Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. / Lazo, A.; Bailer, R. T.; Blakeslee, J. R.; Yanagihara, R.; Stevens, V. C.; Kramer, L.; Lairmore, Michael Dale.

In: Archives of Virology, Vol. 140, No. 2, 02.1995, p. 307-323.

Research output: Contribution to journalArticle

Lazo, A, Bailer, RT, Blakeslee, JR, Yanagihara, R, Stevens, VC, Kramer, L & Lairmore, MD 1995, 'Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates', Archives of Virology, vol. 140, no. 2, pp. 307-323. https://doi.org/10.1007/BF01309864
Lazo A, Bailer RT, Blakeslee JR, Yanagihara R, Stevens VC, Kramer L et al. Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. Archives of Virology. 1995 Feb;140(2):307-323. https://doi.org/10.1007/BF01309864
Lazo, A. ; Bailer, R. T. ; Blakeslee, J. R. ; Yanagihara, R. ; Stevens, V. C. ; Kramer, L. ; Lairmore, Michael Dale. / Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. In: Archives of Virology. 1995 ; Vol. 140, No. 2. pp. 307-323.
@article{883020dad26846a6816efa6bf651ed5d,
title = "Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates",
abstract = "Nucleotide sequence analysis of selected regions of the gag, pol, env and pX genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that African isolates were more closely related to human T-cell lymphotropic virus type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition of distinct STLV-I strains. In this study, we demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that the baboon virus isolates were more closely related to HTLV-I than the Japanese isolates. These results indicate that nucleotide sequence diversity, correlates with variations in proviral restriction enzyme sites and antibody recognition of viral envelope proteins. These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection.",
author = "A. Lazo and Bailer, {R. T.} and Blakeslee, {J. R.} and R. Yanagihara and Stevens, {V. C.} and L. Kramer and Lairmore, {Michael Dale}",
year = "1995",
month = "2",
doi = "10.1007/BF01309864",
language = "English (US)",
volume = "140",
pages = "307--323",
journal = "Archives of Virology",
issn = "0304-8608",
publisher = "Springer Wien",
number = "2",

}

TY - JOUR

T1 - Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates

AU - Lazo, A.

AU - Bailer, R. T.

AU - Blakeslee, J. R.

AU - Yanagihara, R.

AU - Stevens, V. C.

AU - Kramer, L.

AU - Lairmore, Michael Dale

PY - 1995/2

Y1 - 1995/2

N2 - Nucleotide sequence analysis of selected regions of the gag, pol, env and pX genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that African isolates were more closely related to human T-cell lymphotropic virus type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition of distinct STLV-I strains. In this study, we demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that the baboon virus isolates were more closely related to HTLV-I than the Japanese isolates. These results indicate that nucleotide sequence diversity, correlates with variations in proviral restriction enzyme sites and antibody recognition of viral envelope proteins. These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection.

AB - Nucleotide sequence analysis of selected regions of the gag, pol, env and pX genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that African isolates were more closely related to human T-cell lymphotropic virus type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition of distinct STLV-I strains. In this study, we demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that the baboon virus isolates were more closely related to HTLV-I than the Japanese isolates. These results indicate that nucleotide sequence diversity, correlates with variations in proviral restriction enzyme sites and antibody recognition of viral envelope proteins. These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection.

UR - http://www.scopus.com/inward/record.url?scp=0029169127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029169127&partnerID=8YFLogxK

U2 - 10.1007/BF01309864

DO - 10.1007/BF01309864

M3 - Article

C2 - 7535998

AN - SCOPUS:0029169127

VL - 140

SP - 307

EP - 323

JO - Archives of Virology

JF - Archives of Virology

SN - 0304-8608

IS - 2

ER -