Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Myka L. Estes, A Kimberley Usrey

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors - including autoimmunity, infection and fetal reactive antibodies - are associated with ASD. In addition, there is evidence of ongoing immune dysregulation in individuals with ASD and in animal models of this disorder. Recently, several molecular signalling pathways - including pathways downstream of cytokines, the receptor MET, major histocompatibility complex class I molecules, microglia and complement factors - have been identified that link immune activation to ASD phenotypes. Together, these findings indicate that the immune system is a point of convergence for multiple ASD-related genetic and environmental risk factors.

Original languageEnglish (US)
Pages (from-to)469-486
Number of pages18
JournalNature Reviews Neuroscience
Volume16
Issue number8
DOIs
StatePublished - Jul 20 2015

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Brain
Immune System
Gene Components
Cytokine Receptors
Microglia
Major Histocompatibility Complex
Autoimmunity
Autism Spectrum Disorder
Animal Models
Mothers
Phenotype
Antibodies
Infection

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Immune mediators in the brain and peripheral tissues in autism spectrum disorder. / Estes, Myka L.; Usrey, A Kimberley.

In: Nature Reviews Neuroscience, Vol. 16, No. 8, 20.07.2015, p. 469-486.

Research output: Contribution to journalArticle

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