Immune-mediated mechanisms of proteinuria

Lindsey Goetz, Joshua M. Thurman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The kidney is a common target of autoimmune and inflammatory diseases, and one of the most common manifestations of immunologic injury of the kidney is proteinuria. Many cellular and molecular components of the immune system can injure the glomerular capillary wall. Thus, appropriate immune responses to infections as well as maladaptive immune responses in patients with autoimmune diseases can cause glomerular injury and proteinuria. Consequently, immunosuppressive medications are effective for treating many forms of proteinuric renal disease. A large number of new biologic agents capable of blocking or amplifying particular components of the immune system are currently being developed. As our understanding of the pathogenesis of proteinuric kidney diseases improves, these new therapeutic agents will likely improve our ability to treat many of the kidney diseases associated with proteinuria.

Original languageEnglish (US)
Title of host publicationProteinuria
Subtitle of host publicationBasic Mechanisms, Pathophysiology and Clinical Relevance
PublisherSpringer International Publishing
Pages67-84
Number of pages18
ISBN (Electronic)9783319433592
ISBN (Print)9783319433578
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Complement
  • Cytokine
  • Immune
  • Immune-complex
  • Immunoglobulin
  • Inflammation
  • Podocyte
  • Proteinuria
  • Toll-like receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Physics and Astronomy(all)

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