Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence-attenuated SHIV 89.6

Chris J Miller, Kristina Abel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Although live-attenuated human immunodeficiency virus-1 (HIV) vaccines may never be used clinically, these vaccines have provided the most durable protection from intravenous (IV) challenge in the simian immunodeficiency virus (SIV)/rhesus macaque model. Systemic infection with virulence attenuated-simian-human immunodeficiency virus (SHIV) 89.6 provides protection against vaginal SIV challenge. This paper reviews the findings related to the innate and adaptive immune responses and the role of inflammation associated with protection in the SHIV 89.6/SIVmac239 model. By an as yet undefined mechanism, most monkeys vaccinated with live-attenuated SHIV 89.6 mounted effective anti-viral CD8+ T cell responses while avoiding the self-destructive inflammatory cycle found in the lymphoid tissues of unprotected and unvaccinated monkeys.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalJournal of Medical Primatology
Volume34
Issue number5-6 SPEC. ISS.
DOIs
StatePublished - Oct 2005

Keywords

  • AIDS vaccine
  • HIV
  • Inflammation
  • Innate immunity
  • Interferon-alpha CD8+ T cells
  • Interferon-gamma

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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