Abstract
In a cross-sectional study involving subjects from the Reaching for Excellence in Adolescent Health cohort, we examined the associations between HIV status, disease severity, immune activation, and oxidative damage. Subjects (265 HIV-positive and 127 HIV-negative) were young (range: 14-23 years of age) and primarily female (75%) and black (67%). Many subjects, particularly female subjects, were overweight or obese. Relatively few HIV-positive subjects had advanced HIV disease (13%), and 54% were taking antiretroviral therapy (ART). The 2 markers of oxidative damage used in this study (plasma malondialdehyde and protein carbonyl concentrations) did not correlate with each other, and neither was higher in HIV-positive subjects than in HIV-negative controls. Increased oxidative damage was seen in association with male gender, cigarette smoking, marijuana use, immune activation (as indicated by activated CD8+ T-cell counts and plasma C-reactive protein concentration), and use of ART, however. Plasma ceruloplasmin was associated with decreased oxidative damage in HIV-positive subjects, although this association was not seen in those taking ART.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 180-190 |
| Number of pages | 11 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2005 |
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Keywords
- Acute-phase response
- Adolescent
- Black
- C-reactive protein
- Ceruloplasmin
- Female
- Hispanic
- HIV
- Malondialdehyde
- Neopterin
- Obesity
- Oxidative stress
- Protein carbonyl
ASJC Scopus subject areas
- Virology
- Immunology
Cite this
Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents. / Stephensen, Charles B.; Marquis, Grace S.; Douglas, Steven D.; Wilson, Craig M.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 38, No. 2, 01.02.2005, p. 180-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents
AU - Stephensen, Charles B.
AU - Marquis, Grace S.
AU - Douglas, Steven D.
AU - Wilson, Craig M.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - In a cross-sectional study involving subjects from the Reaching for Excellence in Adolescent Health cohort, we examined the associations between HIV status, disease severity, immune activation, and oxidative damage. Subjects (265 HIV-positive and 127 HIV-negative) were young (range: 14-23 years of age) and primarily female (75%) and black (67%). Many subjects, particularly female subjects, were overweight or obese. Relatively few HIV-positive subjects had advanced HIV disease (13%), and 54% were taking antiretroviral therapy (ART). The 2 markers of oxidative damage used in this study (plasma malondialdehyde and protein carbonyl concentrations) did not correlate with each other, and neither was higher in HIV-positive subjects than in HIV-negative controls. Increased oxidative damage was seen in association with male gender, cigarette smoking, marijuana use, immune activation (as indicated by activated CD8+ T-cell counts and plasma C-reactive protein concentration), and use of ART, however. Plasma ceruloplasmin was associated with decreased oxidative damage in HIV-positive subjects, although this association was not seen in those taking ART.
AB - In a cross-sectional study involving subjects from the Reaching for Excellence in Adolescent Health cohort, we examined the associations between HIV status, disease severity, immune activation, and oxidative damage. Subjects (265 HIV-positive and 127 HIV-negative) were young (range: 14-23 years of age) and primarily female (75%) and black (67%). Many subjects, particularly female subjects, were overweight or obese. Relatively few HIV-positive subjects had advanced HIV disease (13%), and 54% were taking antiretroviral therapy (ART). The 2 markers of oxidative damage used in this study (plasma malondialdehyde and protein carbonyl concentrations) did not correlate with each other, and neither was higher in HIV-positive subjects than in HIV-negative controls. Increased oxidative damage was seen in association with male gender, cigarette smoking, marijuana use, immune activation (as indicated by activated CD8+ T-cell counts and plasma C-reactive protein concentration), and use of ART, however. Plasma ceruloplasmin was associated with decreased oxidative damage in HIV-positive subjects, although this association was not seen in those taking ART.
KW - Acute-phase response
KW - Adolescent
KW - Black
KW - C-reactive protein
KW - Ceruloplasmin
KW - Female
KW - Hispanic
KW - HIV
KW - Malondialdehyde
KW - Neopterin
KW - Obesity
KW - Oxidative stress
KW - Protein carbonyl
UR - http://www.scopus.com/inward/record.url?scp=13244290103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13244290103&partnerID=8YFLogxK
U2 - 10.1097/00126334-200502010-00009
DO - 10.1097/00126334-200502010-00009
M3 - Article
C2 - 15671803
AN - SCOPUS:13244290103
VL - 38
SP - 180
EP - 190
JO - Journal of acquired immune deficiency syndromes (1999)
JF - Journal of acquired immune deficiency syndromes (1999)
SN - 1525-4135
IS - 2
ER -