Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans

Kiem Vu, Babette Weksler, Ignacio Romero, Pierre Olivier Couraud, Angela C Gelli

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

Original languageEnglish (US)
Pages (from-to)1803-1807
Number of pages5
JournalEukaryotic Cell
Volume8
Issue number11
DOIs
StatePublished - Nov 2009

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Central Nervous System Infections
Cryptococcus neoformans
Blood-Brain Barrier
Endothelial Cells
Cell Line
Brain
Central Nervous System
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans. / Vu, Kiem; Weksler, Babette; Romero, Ignacio; Couraud, Pierre Olivier; Gelli, Angela C.

In: Eukaryotic Cell, Vol. 8, No. 11, 11.2009, p. 1803-1807.

Research output: Contribution to journalArticle

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