Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans

Kiem Vu; Babette Weksler; Ignacio Romero; Pierre Olivier Couraud; Angela C Gelli

doi:10.1128/EC.00240-09

Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans

Kiem Vu, Babette Weksler, Ignacio Romero, Pierre Olivier Couraud, Angela C Gelli

Pharmacology

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83 Scopus citations

Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

Original language	English (US)
Pages (from-to)	1803-1807
Number of pages	5
Journal	Eukaryotic Cell
Volume	8
Issue number	11
DOIs	https://doi.org/10.1128/EC.00240-09
State	Published - Nov 2009

ASJC Scopus subject areas

Microbiology
Molecular Biology

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Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans. / Vu, Kiem; Weksler, Babette; Romero, Ignacio; Couraud, Pierre Olivier; Gelli, Angela C.

In: Eukaryotic Cell, Vol. 8, No. 11, 11.2009, p. 1803-1807.

Research output: Contribution to journal › Article › peer-review

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Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans

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