Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by cryptococcus neoformans

Kiem Vu, Babette Weksler, Ignacio Romero, Pierre Olivier Couraud, Angela C Gelli

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

Original languageEnglish (US)
Pages (from-to)1803-1807
Number of pages5
JournalEukaryotic Cell
Volume8
Issue number11
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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