Immediate zidovudine treatment protects simian immunodeficiency virus- infected newborn macaques against rapid onset of AIDS

K. K A Van Rompay; M. G. Otsyula; Marta Marthas; Chris J Miller; M. B. McChesney; Niels C Pedersen

Immediate zidovudine treatment protects simian immunodeficiency virus- infected newborn macaques against rapid onset of AIDS

K. K A Van Rompay, M. G. Otsyula, Marta Marthas, Chris J Miller, M. B. McChesney, Niels C Pedersen

Research output: Contribution to journal › Article › peer-review

Abstract

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIV(mac) resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects.

Original language	English (US)
Pages (from-to)	125-131
Number of pages	7
Journal	Antimicrobial Agents and Chemotherapy
Volume	39
Issue number	1
State	Published - 1995

ASJC Scopus subject areas

Pharmacology (medical)

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Immediate zidovudine treatment protects simian immunodeficiency virus- infected newborn macaques against rapid onset of AIDS. / Van Rompay, K. K A; Otsyula, M. G.; Marthas, Marta ; Miller, Chris J; McChesney, M. B.; Pedersen, Niels C.

In: Antimicrobial Agents and Chemotherapy, Vol. 39, No. 1, 1995, p. 125-131.

Research output: Contribution to journal › Article › peer-review

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abstract = "Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIV(mac) resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects.",

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AB - Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIV(mac) resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects.

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