Immediate and late outcomes of transarterial coil occlusion of patent ductus arteriosus in dogs

F. E. Campbell, W. P. Thomas, S. J. Miller, D. Berger, Mark D Kittleson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Records from dogs (n = 125) that underwent attempted transarterial coil occlusion of patent ductus arteriosus (PDA) at the University of California, Davis, between 1998 and 2003, were reviewed, and a subset of these dogs (n = 31) in which the procedure was performed at least 12 months earlier were reexamined to determine long-term outcome. Coil implantation was achieved in 108 dogs (86%). Despite immediate complete ductal closure in only 34% of dogs, the procedure was hemodynamically successful as evidenced by a reduction in indexed left ventricular internal diameter in diastole (LVIDd; P < .0001), fractional shortening (P < .0001), and left atrial to aortic ratio (LA:Ao; P = .022) within 24 hours. Complete ductal closure was documented in 61% of dogs examined 12 to 63 months after coil occlusion. Long-standing residual ductal flow in the other 39% of dogs was not associated with increased indexed LVIDd or LA:Ao and was not hemodynamically relevant. Repeat intervention was deemed advisable in only 4 dogs with persistent (n = 1) or recurrent (n = 3) ductal flow. Complications included aberrant embolization (n = 27), death (n = 3), ductal reopening (n = 3), transient hemoglobinuria (n = 2), hemorrhage (n = 1), aberrant coil placement (n = 1), pulmonary hypertension (n = 1), and skin abscessation (n = 1). Serious infectious complications did not occur despite antibiotic administration to only 40% of these dogs. Transarterial coil occlusion was not possible in 14 dogs (11%) because of coil instability in the PDA and was associated with increased indexed minimum ductal diameter (P = .03), LVIDd (P = .0002), LVIDs (P = 0.001), and congestive left heart failure (P = .03) reflecting a relatively large shunt volume.

Original languageEnglish (US)
Pages (from-to)83-96
Number of pages14
JournalJournal of Veterinary Internal Medicine
Volume20
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

patent ductus arteriosus
Patent Ductus Arteriosus
Dogs
dogs
Hemoglobinuria
hemoglobinuria
Diastole
heart failure
Pulmonary Hypertension
skin (animal)
shortenings
hypertension
hemorrhage
Heart Failure
antibiotics
lungs
Hemorrhage
death
Anti-Bacterial Agents
Skin

Keywords

  • Canine
  • Coil embolization
  • Congenital heart disease
  • Echocardiography

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Immediate and late outcomes of transarterial coil occlusion of patent ductus arteriosus in dogs. / Campbell, F. E.; Thomas, W. P.; Miller, S. J.; Berger, D.; Kittleson, Mark D.

In: Journal of Veterinary Internal Medicine, Vol. 20, No. 1, 01.2006, p. 83-96.

Research output: Contribution to journalArticle

Campbell, F. E. ; Thomas, W. P. ; Miller, S. J. ; Berger, D. ; Kittleson, Mark D. / Immediate and late outcomes of transarterial coil occlusion of patent ductus arteriosus in dogs. In: Journal of Veterinary Internal Medicine. 2006 ; Vol. 20, No. 1. pp. 83-96.
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abstract = "Records from dogs (n = 125) that underwent attempted transarterial coil occlusion of patent ductus arteriosus (PDA) at the University of California, Davis, between 1998 and 2003, were reviewed, and a subset of these dogs (n = 31) in which the procedure was performed at least 12 months earlier were reexamined to determine long-term outcome. Coil implantation was achieved in 108 dogs (86{\%}). Despite immediate complete ductal closure in only 34{\%} of dogs, the procedure was hemodynamically successful as evidenced by a reduction in indexed left ventricular internal diameter in diastole (LVIDd; P < .0001), fractional shortening (P < .0001), and left atrial to aortic ratio (LA:Ao; P = .022) within 24 hours. Complete ductal closure was documented in 61{\%} of dogs examined 12 to 63 months after coil occlusion. Long-standing residual ductal flow in the other 39{\%} of dogs was not associated with increased indexed LVIDd or LA:Ao and was not hemodynamically relevant. Repeat intervention was deemed advisable in only 4 dogs with persistent (n = 1) or recurrent (n = 3) ductal flow. Complications included aberrant embolization (n = 27), death (n = 3), ductal reopening (n = 3), transient hemoglobinuria (n = 2), hemorrhage (n = 1), aberrant coil placement (n = 1), pulmonary hypertension (n = 1), and skin abscessation (n = 1). Serious infectious complications did not occur despite antibiotic administration to only 40{\%} of these dogs. Transarterial coil occlusion was not possible in 14 dogs (11{\%}) because of coil instability in the PDA and was associated with increased indexed minimum ductal diameter (P = .03), LVIDd (P = .0002), LVIDs (P = 0.001), and congestive left heart failure (P = .03) reflecting a relatively large shunt volume.",
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