Abstract
Vincristine was given to pregnant mice on day 7 1/2 of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9 1/2 of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10 1/2 most embryos were either developmentally retarded by the treatment or malformed. The morphologically 'normal' embryos removed on day 9 1/2 of pregnancy were cultured in vitro for 24 hr. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly 'normal' period of embryonic development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 49-55 |
| Number of pages | 7 |
| Journal | Journal of Experimental Zoology |
| Volume | 227 |
| Issue number | 1 |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Animal Science and Zoology
Cite this
Immediate and delayed effects of vincristine administered during early postimplantation stages of murine embryogenesis. / Wan, Yu-Jui Yvonne; Wu, T. C.; Damjanov, I.
In: Journal of Experimental Zoology, Vol. 227, No. 1, 1983, p. 49-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immediate and delayed effects of vincristine administered during early postimplantation stages of murine embryogenesis
AU - Wan, Yu-Jui Yvonne
AU - Wu, T. C.
AU - Damjanov, I.
PY - 1983
Y1 - 1983
N2 - Vincristine was given to pregnant mice on day 7 1/2 of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9 1/2 of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10 1/2 most embryos were either developmentally retarded by the treatment or malformed. The morphologically 'normal' embryos removed on day 9 1/2 of pregnancy were cultured in vitro for 24 hr. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly 'normal' period of embryonic development.
AB - Vincristine was given to pregnant mice on day 7 1/2 of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9 1/2 of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10 1/2 most embryos were either developmentally retarded by the treatment or malformed. The morphologically 'normal' embryos removed on day 9 1/2 of pregnancy were cultured in vitro for 24 hr. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly 'normal' period of embryonic development.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020568110&partnerID=8YFLogxK
M3 - Article
C2 - 6619766
AN - SCOPUS:0020568110
VL - 227
SP - 49
EP - 55
JO - Journal of Experimental Zoology
JF - Journal of Experimental Zoology
SN - 1552-5007
IS - 1
ER -