Abstract
Vincristine was given to pregnant mice on day 7 1/2 of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9 1/2 of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10 1/2 most embryos were either developmentally retarded by the treatment or malformed. The morphologically 'normal' embryos removed on day 9 1/2 of pregnancy were cultured in vitro for 24 hr. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly 'normal' period of embryonic development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 49-55 |
| Number of pages | 7 |
| Journal | Journal of Experimental Zoology |
| Volume | 227 |
| Issue number | 1 |
| State | Published - 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- Animal Science and Zoology