Imbalanced estrogen metabolism in the brain: Possible relevance to the etiology of Parkinson's disease

Nilesh W. Gaikwad, Daniel Murman, Cheryl L. Beseler, Muhammad Zahid, Eleanor G. Rogan, Ercole L. Cavalieri

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

Original languageEnglish (US)
Pages (from-to)434-444
Number of pages11
JournalBiomarkers
Volume16
Issue number5
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Catechol estrogen quinones
  • Depurinating estrogenDNA adducts
  • UPLC-MS/MS
  • Urinary biomarkers

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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