Imaging voltage and brain chemistry with genetically encoded sensors and modulators

Akash Pal, Lin Tian

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Neurons and glia are functionally organized into circuits and higher-order structures that allow the precise information processing required for complex behaviors. To better understand the structure and function of the brain, we must understand synaptic connectivity, action potential generation and propagation, as well as well-orchestrated molecular signaling. Recently, dramatically improved sensors for voltage, intracellular calcium, and neurotransmitters/modulators, combined with advanced microscopy provide new opportunities for in vivo dissection of cellular and circuit activity in awake, behaving animals. This review focuses on the current trends in genetically encoded sensors for molecules and cellular events and their potential applicability to the study of nervous system in health and disease.

Original languageEnglish (US)
Pages (from-to)166-176
Number of pages11
JournalCurrent Opinion in Chemical Biology
StatePublished - Aug 2020


  • Bioluminescence
  • GECI
  • Genetically encoded sensors
  • GEVI
  • GEZI

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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