Imaging of tissue microstructures using a multimodal microscope design

Stavros G. Demos, Chad A. Lieber, Bevin Lin, Rajendra Ramsamooj

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We investigate a microscope design that offers high signal sensitivity and hyperspectral imaging capabilities and allows for implementation of various optical imaging approaches while its operational complexity is minimized. This system uses long working distance microscope objectives that enable for offaxis illumination of the tissue, thereby allowing for excitation at any optical wavelength and nearly eliminating spectral noise from the optical elements. Preliminary studies using human and animal tissues demonstrate the feasibility of this approach for real-time imaging of intact tissue microstructures using autofluorescence and light scattering imaging methods.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume11
Issue number4
DOIs
StatePublished - Jul 2005

Keywords

  • Fluorescence microscopy
  • Medical and biological imaging
  • Microscopy
  • Tissue diagnostics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

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