Imaging objects in tissuelike media with optical tagging and the diffuse photon differential transmittance

X. D. Zhu, Sung Po Wei, Xiao Wen Guo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In a proof-of-concept experiment, we optically tagged objects embedded in an inhomogeneous and multiple-scattering medium and measured the difference between the transmitted diffuse photons at two optical wavelengths, one at and the other off a sharp absorption peak of the exogenous contrast agent. We demonstrated that the visibility of tagged objects was significantly enhanced in comparison with that of untagged objects. From our analysis it seems possible to use dual-wavelength differential transmittance spectrometry together with monoclonal-antibody-delivered optical contrast agents to detect tumors as small as 0.1-0.3 cm in size and embedded as deeply as a few centimeters beneath a tissue surface.

Original languageEnglish (US)
Pages (from-to)300-305
Number of pages6
JournalJournal of the Optical Society of America A: Optics and Image Science, and Vision
Volume14
Issue number1
StatePublished - 1997

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Computer Vision and Pattern Recognition
  • Engineering(all)

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