Image quantification with a large area multiwire proportional chamber positron camera (MUP-PET)

Simon R Cherry, P. K. Marsden, R. J. Ott, M. A. Flower, S. Webb, J. W. Babich

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A large area multi wire proportional chamber positron camera system is under evaluation for clinical Nuclear Medicine investigation using isotopes both from in house generators (68Ga) and from remote cyclotrons (18F,124I,64Cu and81Rb). Images are reconstructed using a fully three dimensional (3D) algorithm and exhibit equal resolution in all three orthogonal directions. The axial field of view of 15 cm is large enough to allow coverage of the whole brain. This paper discusses the performance of the MUP-PET system with particular emphasis on quantification and the development of an attenuation correction scheme for a large area detector system. The distribution of scattered and accidental events is investigated and observed to contribute a fairly uniform background to the image. Dead time correction factors are calculated from an analytical expression obtained by considering the various sources of dead time present in the system. Following correction for atternuation, accidentals, scattered events and dead time, reconstructed phantom images show a strong linear correlation (r=0.998) between count density and regional isotope concentration. The extension of the methods to clinical studies is discussed.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalEuropean Journal Of Nuclear Medicine
Volume15
Issue number11
DOIs
StatePublished - Nov 1989
Externally publishedYes

    Fingerprint

Keywords

  • Attenuation correction
  • Large area detectors
  • Positron emission tomography
  • Quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this