Abstract
Cytokines play a critical role in the pathogenesis of psoriatic arthritis, ankylosing spondylitis, and other types of spondyloarthritis (SpA). Besides IFN-γ and TNF-α; IL-23/IL-17 cytokines play a dominant role in the inflammatory and proliferative cascades of SpA. Recently, in a series of elegant experiments using mouse models and human tissues, it has been demonstrated that IL-23-induced Th17 cytokines (IL-17 and IL-22) can contribute to following pathologic events associated with SpA: development of psoriatic plaque, pannus formation in the joint, joint erosion, and new bone formation. In this review article, we have discussed the contributing role of the IL-23/IL-17 cytokine axis in the pathogenesis of PsA and AS. IL-23/IL-17-targeted therapies are very promising for SpA, and we have provided an outline about usefulness of these new groups of biologics in SpA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1437-1441 |
| Number of pages | 5 |
| Journal | Clinical Rheumatology |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2016 |
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Keywords
- Ankylosing spoindylitis
- IL-17
- IL-23
- Psoriatic arthritis
- Spondyloarthritis
- Th17 Cell
ASJC Scopus subject areas
- Rheumatology
Cite this
IL-23/IL-17 axis in spondyloarthritis-bench to bedside. / Raychaudhuri, Siba P; Raychaudhuri, Smriti K.
In: Clinical Rheumatology, Vol. 35, No. 6, 01.06.2016, p. 1437-1441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IL-23/IL-17 axis in spondyloarthritis-bench to bedside
AU - Raychaudhuri, Siba P
AU - Raychaudhuri, Smriti K.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Cytokines play a critical role in the pathogenesis of psoriatic arthritis, ankylosing spondylitis, and other types of spondyloarthritis (SpA). Besides IFN-γ and TNF-α; IL-23/IL-17 cytokines play a dominant role in the inflammatory and proliferative cascades of SpA. Recently, in a series of elegant experiments using mouse models and human tissues, it has been demonstrated that IL-23-induced Th17 cytokines (IL-17 and IL-22) can contribute to following pathologic events associated with SpA: development of psoriatic plaque, pannus formation in the joint, joint erosion, and new bone formation. In this review article, we have discussed the contributing role of the IL-23/IL-17 cytokine axis in the pathogenesis of PsA and AS. IL-23/IL-17-targeted therapies are very promising for SpA, and we have provided an outline about usefulness of these new groups of biologics in SpA.
AB - Cytokines play a critical role in the pathogenesis of psoriatic arthritis, ankylosing spondylitis, and other types of spondyloarthritis (SpA). Besides IFN-γ and TNF-α; IL-23/IL-17 cytokines play a dominant role in the inflammatory and proliferative cascades of SpA. Recently, in a series of elegant experiments using mouse models and human tissues, it has been demonstrated that IL-23-induced Th17 cytokines (IL-17 and IL-22) can contribute to following pathologic events associated with SpA: development of psoriatic plaque, pannus formation in the joint, joint erosion, and new bone formation. In this review article, we have discussed the contributing role of the IL-23/IL-17 cytokine axis in the pathogenesis of PsA and AS. IL-23/IL-17-targeted therapies are very promising for SpA, and we have provided an outline about usefulness of these new groups of biologics in SpA.
KW - Ankylosing spoindylitis
KW - IL-17
KW - IL-23
KW - Psoriatic arthritis
KW - Spondyloarthritis
KW - Th17 Cell
UR - http://www.scopus.com/inward/record.url?scp=84963686147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963686147&partnerID=8YFLogxK
U2 - 10.1007/s10067-016-3263-4
DO - 10.1007/s10067-016-3263-4
M3 - Article
VL - 35
SP - 1437
EP - 1441
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 6
ER -