Ikarugamycin: Total synthesis of the decahydro-as-indacene portion

Mark J. Kurth, Dennis H. Burns, Michael J. O'Brien

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


An efficient, stereoselective synthesis of octahydro-as-indacenone 2, the carbocycle fragment of the antibiotic ikarugamycin, is described. The prominent step in this sequence is an intramolecular Diels-Alder reaction, which establishes the relative stereochemistry of 2.

Original languageEnglish (US)
Pages (from-to)731-733
Number of pages3
JournalJournal of Organic Chemistry
Issue number4
StatePublished - 1984

ASJC Scopus subject areas

  • Organic Chemistry


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