IgG4-related disease: Changing epidemiology and new thoughts on a multisystem disease

Annarosa Floreani, Kazuichi Okazaki, Kazushige Uchida, M. Eric Gershwin

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


IgG4-related disease (IgG4-RD) represents an immune-mediated fibroinflammatory condition with peculiar histopathologic changes that can affect various organs. In 2012 its unified nomenclature was published, which allows to abandon other synonymous names. Up to now, only little is known about its epidemiology around the world. However, although it is generally considered a rare condition, the number of patients with IgG4-RD is increasing enormously. Likewise, the annual number of publications on this subject has increased progressively. The spectrum of clinical manifestations in IgG4-RD is highly variable, depending on the severity of the disease as well as the presence of organ(s) involvement. This review gives an overview on changing epidemiology of IgG4-RD focusing the attention on the large cohorts of patients published in the literature.

Original languageEnglish (US)
Article number100074
JournalJournal of Translational Autoimmunity
StatePublished - Jan 2021


  • Epidemiology
  • Genetic factors
  • IgG4
  • IgG4-related disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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