IgE, mast cells, and eosinophils in atopic dermatitis

Fu-Tong Liu, Heidi Goodarzi, Huan Yuan Chen

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

Original languageEnglish (US)
Pages (from-to)298-310
Number of pages13
JournalClinical Reviews in Allergy and Immunology
Volume41
Issue number3
DOIs
StatePublished - Dec 2011

Fingerprint

Atopic Dermatitis
Eosinophils
Mast Cells
Immunoglobulin E
Skin Abnormalities
Eosinophilia
Therapeutic Uses
Chemokines
Skin Diseases

Keywords

  • Atopic dermatitis
  • Eosinophils
  • IgE
  • Mast cells

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

IgE, mast cells, and eosinophils in atopic dermatitis. / Liu, Fu-Tong; Goodarzi, Heidi; Chen, Huan Yuan.

In: Clinical Reviews in Allergy and Immunology, Vol. 41, No. 3, 12.2011, p. 298-310.

Research output: Contribution to journalArticle

Liu, Fu-Tong ; Goodarzi, Heidi ; Chen, Huan Yuan. / IgE, mast cells, and eosinophils in atopic dermatitis. In: Clinical Reviews in Allergy and Immunology. 2011 ; Vol. 41, No. 3. pp. 298-310.
@article{38321f30bc184e3498c9ad1004b261cb,
title = "IgE, mast cells, and eosinophils in atopic dermatitis",
abstract = "Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.",
keywords = "Atopic dermatitis, Eosinophils, IgE, Mast cells",
author = "Fu-Tong Liu and Heidi Goodarzi and Chen, {Huan Yuan}",
year = "2011",
month = "12",
doi = "10.1007/s12016-011-8252-4",
language = "English (US)",
volume = "41",
pages = "298--310",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - IgE, mast cells, and eosinophils in atopic dermatitis

AU - Liu, Fu-Tong

AU - Goodarzi, Heidi

AU - Chen, Huan Yuan

PY - 2011/12

Y1 - 2011/12

N2 - Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

AB - Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

KW - Atopic dermatitis

KW - Eosinophils

KW - IgE

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=80054905882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054905882&partnerID=8YFLogxK

U2 - 10.1007/s12016-011-8252-4

DO - 10.1007/s12016-011-8252-4

M3 - Article

C2 - 21249468

AN - SCOPUS:80054905882

VL - 41

SP - 298

EP - 310

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 3

ER -