IFNG, a double-edged sword in cancer immunity and metastasis

Chengfei Liu, Allen C Gao

Research output: Contribution to journalArticle

Abstract

IFNg has antitumorigenic effects; however, the findings of IFNg in promoting the tumor cell survival and inducing adaptive immune resistance via CD4 þ T-cell loss and programmed death ligand 1 (PD-L1) upregulation challenge this concept. Lo and colleagues determined that IFNg induces epithelial–mesenchymal transition (EMT) by regulating the turnover of miRNA in prostate cancer, emphasizing the duplicitous effects of IFNg. IFIT5, an IFN-induced tetratricopeptide repeat (IFIT) family member, was found to form a complex with the exoribonuclease-XRN1 to process miRNA maturation. These findings unveil a new IFNg–STAT1–IFIT5–miRNA–EMT pathway in prostate cancer progression. The biphasic effects of IFNg in prostate cancer raise concerns about its therapeutic application, which need to be evaluated in future studies.

Original languageEnglish (US)
Pages (from-to)1032-1033
Number of pages2
JournalCancer Research
Volume79
Issue number6
DOIs
StatePublished - Jan 1 2019

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Immunity
Prostatic Neoplasms
Neoplasm Metastasis
MicroRNAs
Exoribonucleases
Neoplasms
Cell Survival
Up-Regulation
Ligands
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

IFNG, a double-edged sword in cancer immunity and metastasis. / Liu, Chengfei; Gao, Allen C.

In: Cancer Research, Vol. 79, No. 6, 01.01.2019, p. 1032-1033.

Research output: Contribution to journalArticle

Liu, Chengfei ; Gao, Allen C. / IFNG, a double-edged sword in cancer immunity and metastasis. In: Cancer Research. 2019 ; Vol. 79, No. 6. pp. 1032-1033.
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