Abstract
IFNg has antitumorigenic effects; however, the findings of IFNg in promoting the tumor cell survival and inducing adaptive immune resistance via CD4 þ T-cell loss and programmed death ligand 1 (PD-L1) upregulation challenge this concept. Lo and colleagues determined that IFNg induces epithelial–mesenchymal transition (EMT) by regulating the turnover of miRNA in prostate cancer, emphasizing the duplicitous effects of IFNg. IFIT5, an IFN-induced tetratricopeptide repeat (IFIT) family member, was found to form a complex with the exoribonuclease-XRN1 to process miRNA maturation. These findings unveil a new IFNg–STAT1–IFIT5–miRNA–EMT pathway in prostate cancer progression. The biphasic effects of IFNg in prostate cancer raise concerns about its therapeutic application, which need to be evaluated in future studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1032-1033 |
| Number of pages | 2 |
| Journal | Cancer Research |
| Volume | 79 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
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IFNG, a double-edged sword in cancer immunity and metastasis. / Liu, Chengfei; Gao, Allen C.
In: Cancer Research, Vol. 79, No. 6, 01.01.2019, p. 1032-1033.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IFNG, a double-edged sword in cancer immunity and metastasis
AU - Liu, Chengfei
AU - Gao, Allen C
PY - 2019/1/1
Y1 - 2019/1/1
N2 - IFNg has antitumorigenic effects; however, the findings of IFNg in promoting the tumor cell survival and inducing adaptive immune resistance via CD4 þ T-cell loss and programmed death ligand 1 (PD-L1) upregulation challenge this concept. Lo and colleagues determined that IFNg induces epithelial–mesenchymal transition (EMT) by regulating the turnover of miRNA in prostate cancer, emphasizing the duplicitous effects of IFNg. IFIT5, an IFN-induced tetratricopeptide repeat (IFIT) family member, was found to form a complex with the exoribonuclease-XRN1 to process miRNA maturation. These findings unveil a new IFNg–STAT1–IFIT5–miRNA–EMT pathway in prostate cancer progression. The biphasic effects of IFNg in prostate cancer raise concerns about its therapeutic application, which need to be evaluated in future studies.
AB - IFNg has antitumorigenic effects; however, the findings of IFNg in promoting the tumor cell survival and inducing adaptive immune resistance via CD4 þ T-cell loss and programmed death ligand 1 (PD-L1) upregulation challenge this concept. Lo and colleagues determined that IFNg induces epithelial–mesenchymal transition (EMT) by regulating the turnover of miRNA in prostate cancer, emphasizing the duplicitous effects of IFNg. IFIT5, an IFN-induced tetratricopeptide repeat (IFIT) family member, was found to form a complex with the exoribonuclease-XRN1 to process miRNA maturation. These findings unveil a new IFNg–STAT1–IFIT5–miRNA–EMT pathway in prostate cancer progression. The biphasic effects of IFNg in prostate cancer raise concerns about its therapeutic application, which need to be evaluated in future studies.
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UR - http://www.scopus.com/inward/citedby.url?scp=85062945221&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-19-0083
DO - 10.1158/0008-5472.CAN-19-0083
M3 - Article
VL - 79
SP - 1032
EP - 1033
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 6
ER -