IFNγ mediates DUOX2 expression via a STAT-independent signaling pathway

Thomas Hill, Changhong Xu, Richart W Harper

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The biological roles of the dual oxidases, DUOX1 and DUOX2, are dependent upon the tissue in which they are expressed. However, the mechanisms that control DUOX expression in these tissues are largely unexplored. Given the known role of DUOX for host defense in the gut and respiratory tract, we characterized potential mechanisms that control DUOX2 expression in response to interferon gamma (IFNγ) in respiratory tract epithelium. We discovered that IFNγ-mediated DUOX2 expression was regulated by a STAT-independent, JAK-independent pathway. These data provide insights into a novel IFNγ signaling pathway with potential importance for regulation of host defense responses.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume395
Issue number2
DOIs
StatePublished - Apr 30 2010

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Keywords

  • Dual oxidase
  • DUOX
  • Gamma interferon
  • JAK
  • Signaling
  • STAT

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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