Idiopathic Photoreceptor Dysfunction Causes Unexplained Visual Acuity Loss in Later Adulthood

Susan E. Rowe, Jonathan D. Trobe, Paul A. Sieving

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Progressive visual loss, caused by initially unrecognized retinal photoreceptor dysfunction predominantly affecting cones, developed in six patients in late adulthood. Because of minimal ophthalmoscopic retinal abnormalities, the patients initially had been suspected of having optic neuropathy or psychogenic visual loss. The correct diagnosis was ultimately established by finding electroretinographic abnormalities and color discrimination losses out of proportion to visual acuity loss. In no case was a causative agent or a family history of photoreceptor disease identified. In many other respects, however, features of the patients' illness resemble those described previously under the headings of cone dysfunction syndrome, cone dystrophy, cone degeneration, and conerod dystrophy.

Original languageEnglish (US)
Pages (from-to)1632-1637
Number of pages6
Issue number12
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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