Idiopathic hypereosinophilic syndrome in 3 rottweilers

Jane E Sykes, Douglas J. Weiss, Lance C. Buoen, Melissa M. Blauvelt, David W. Hayden

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Three Rottweilers with marked peripheral eosinophilia and infiltration of the liver, spleen, lungs, and bone marrow with eosinophils were diagnosed with idiopathic hypereosinophilic syndrome (IHES). Mean serum immunoglobulin E concentrations were markedly high. On cytogenetic analysis, no evidence of karyotypic abnormalities was found in bone marrow aspirates. Despite an extensive search, no underlying cause for the eosinophilia could be identified. In this study, cytogenetic analysis and measurement of serum IgE concentrations were used to differentiate IHES and eosinophilic leukemia.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalJournal of Veterinary Internal Medicine
Issue number2
StatePublished - 2001
Externally publishedYes


  • Cytogenetic analysis
  • Dogs
  • Eosinophilic gastroenteritis
  • Eosinophilic leukemia
  • Immunoglobulin E
  • Splendore-Hoeppli phenomenon

ASJC Scopus subject areas

  • veterinary(all)


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