Idiopathic chronic diarrhea in rhesus macaques is not associated with enteric viral infections

Eric Delwart, Michael J. Tisza, Eda Altan, Yanpeng Li, Xutao Deng, Dennis J. Hartigan-O’connor, Amir Ardeshir

Research output: Contribution to journalArticlepeer-review


While recent changes in treatment have reduced the lethality of idiopathic chronic diarrhea (ICD), this condition remains one of the most common causes of rhesus macaque deaths in non-human primate research centers. We compared the viromes in fecal swabs from 52 animals with late stage ICD and 41 healthy animals. Viral metagenomics targeting virus-like particles was used to identify viruses fecally shed by each animal. Five viruses belonging to the Picornaviridae, one to the Caliciviridae, one to the Parvoviridae, and one to the Adenoviridae families were identified. The fraction of reads matching each viral species was then used to estimate and compare viral loads in ICD cases versus healthy controls. None of the viruses detected in fecal swabs were strongly associated with ICD.

Original languageEnglish (US)
Article number2503
Issue number12
StatePublished - Dec 2021


  • Cenote-Taker 2
  • Disease association
  • Idiopathic chronic diarrhea
  • Viral metagenomics
  • Virome

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


Dive into the research topics of 'Idiopathic chronic diarrhea in rhesus macaques is not associated with enteric viral infections'. Together they form a unique fingerprint.

Cite this